EXM 3000

Nucleic Acid Isolation System The EXM3000 is designed as a high-tech instrument to isolate and purify the nucleic acid through magnetic bead method featuring more efficient extraction, smaller size and safer operation. Key Features ✓ Requires 9 minutes only to extract 32 samples ✓ Magnetic flux is up to 5500 GS, avoiding the risk of magnetic bead down ✓ Recovery Rate ≥ 98% ✓ CV ≤ 3% ✓ With Hepa Filter and UV Sterilization

Thermo Fisher SCIENTIFIC

TDE Series Ultra-Low Temperature Freezers

Part of the Standard Performance (STP) family, Thermo ScientificTM TDE Series ultra-low temperature freezers, powered by H-drive, feature four upright models, maximizing storage capacity from 30,000 up to 60,000 2mL vials. The TDE Series is a sustainable and reliable solution with ultimate sample security and operational savings for every lab. From our first ULT freezer in 1940 to today, the combined experience of REVCO, Forma Scientific, Jewett, Harris, and other families of products continues to drive our ability to deliver industry-leading innovations that help accelerate science and health care. Features and Benefits Performance ▪ Powered by H-drive’s hydrocarbon technology, these systems save up to 25% in energy usage and heat rejection over conventional refrigerant ultra-low freezers1 ▪ Designed for daily usage, recovers cabinet temperature 20% faster after opening the door.2 ▪ A quiet sound output below 53 dBA, enables the freezer to come out of the hallway and into the lab ▪ Meets +/-10°C validation protocols at -80°C with strong peak variation and steady-state temperature variation ▪ Natural hydrocarbon refrigerants reduce system operating stresses promoting outstanding reliability and worry-free sample protection User Friendly ▪ The H-drive Information Center (HIC) combines easy to read temperature with simple capacitive touch buttons in a 5.6” display ▪ Four capacities (300, 400, 500 and 600 2-inch box) to accommodate a variety of storage needs and lab footprint specifications ▪ All models contain four inner doors allowing for easy sample access without exposing greater freezer content to ambient conditions ▪ Improved customer convenience with new ergonomically designed handle, high contrast eye- level display, and comfortable easy-access shelf locations. ▪ Compatible with most racking systems including a full range of Thermo ScientificTM racks for boxes, microplates, Thermo ScientificTM MatrixTM and Nunc CryoBankTM tubes ▪ Security features including alarm settings and padlock-compatible doors Sustainability ▪ Manufactured in an award-winning, zero-waste to landfill facility ▪ Lower HVAC costs as a result of less heat emission into the environment ▪ Natural refrigerants and water-blown foam insulation, making the Series compliant with the U.S. Environmental Protection Agency’s Significant New Alternatives Policy (SNAP), the European Union’s F-Gas and other sustainability standards Get Connected The Thermo ScientificTM DeviceLinkTM Connect remote monitoring solution helps provide peace of mind by enabling you to keep track of your equipment anytime, anywhere. This system supports independent sensors to monitor your instrument, but it can also be connected via serial port directly to the instrument, harnessing the on-board telemetry data, alarms, and events. All information is transmitted to the Thermo Fisher Connect cloud platform where you have 24/7 access to the information via InstrumentConnect’s web- and mobile-based applications. For more information visit www.thermofisher.com/dlc. Compatible DeviceLink Connect System Cat. No. Description DLCKTULTS101 Ultra-low temperature freezer *Each kit includes a DeviceLink Connect system, 1-year basic monitoring subscription, power cable, commissioner USB, mounting hardware, and an applicable serial or USB cable. Independent DeviceLink Connect Sensors Cat. No. Description DLCSKTEMP001 DeviceLink Connect PT100 (-200°C to +600°C) temperature sensor and Smart-Cable adapter DLCSKCURT001 DeviceLink Connect current transducer (0-50A) with Smart-Cable adapter DLCPTDOOR001 Door Switch Footnotes: 1. Internal data comparing 11.2 kWh/day to UXF600 = 14.9 kWh/day. Data on file. 2. Typical freezer test data based on internal testing in ambient temperature at 20°C; Typical standard validation protocol of +/-10°C. Performance Data: Standard Mode Model Energy Consumption* Peak Variation from Setpoint** Sound 1-min Door Opening Recovery to -75°C Warm Up Time (- 80°C to - 50°C)*** UOM (kW-hr/day) (°C) (dBa) (min) (min) TDE30086FA 11.2 +7.1 / -6.1 51.5 13 255 TDE30086FD 11.0 +6.0 / -4.5 51.5 14 277 TDE30086FV 9.2 +6.3 / -3.6 51.5 11 268 TDE30086LA 11.2 +7.1 / -6.1 51.5 13 255 TDE30086LD 11.0 +6.0 / -4.5 51.5 14 277 TDE30086LV 9.2 +6.3 / -3.6 51.5 11 268 TDE40086FA 12.9 +6.0 / -4.0 50.8 16 277 TDE40086FD 10.4 +7.0 / -3.8 50.8 16 305 TDE40086FV 10.4 +5.7 / -3.5 50.8 15 271 TDE40086LA 12.9 +6.0 / -4.0 50.8 16 277 TDE40086LD 10.4 +7.0 / -3.8 50.8 16 305 TDE40086LV 10.4 +5.7 / -3.5 50.8 15 271 TDE50086FA 12.8 +4.5 / -3.2 50.0 21 302 TDE50086FD 11.9 +5.7 / -3.2 51.0 23 304 TDE50086FV 10.3 +4.2 / -3.8 50.0 16 312 TDE50086LA 12.8 +4.5 / -3.2 50.0 21 302 TDE50086LD 11.9 +5.7 / -3.2 51.0 23 304 TDE50086LV 10.3 +4.2 / -3.8 50.0 16 312 TDE60086FA 13.6 +4.6 / -3.3 50.5 22 343 TDE60086FD 13.3 +6.0 / -2.7 50.5 28 329 TDE60086FV 11.9 +5.8 / -3.3 50.5 21 352 TDE60086LA 13.6 +4.6 / -3.3 50.5 22 343 TDE60086LD 13.3 +6.0 / -2.7 50.5 28 329 TDE60086LV 11.9 +5.8 / -3.3 50.5 21 352 * Energy Calculation: Typical freezer data based on internal testing with freezer setpoint at -80°C and ambient temperature at 20°C ** Peak Variation From Setpoint: Typical freezer data based on internal testing with freezer setpoint at - 80°C and ambient temperature at 20°C *** Warm Up Time: Typical freezer data based on internal testing with freezer setpoint at -80°C and ambient temperature at 20°C

Thermo Fisher SCIENTIFIC

TSX Series High-Performance -20°C Manual Defrost Freezers

Thermo ScientificTM TSX Series high-performance -20°C manual defrost freezers are designed are designed for applications in which even slight intermittent coil warming during auto defrost cannot be tolerated. The design supports sample protection and sustainability objectives for the storage of enzymes, reagents, pharmaceuticals, vaccines, biological and other commonly used laboratory and clinical materials. The Series’ V-drive technology is designed to provide temperature uniformity that continually adapts to user patterns, offering significant energy savings without compromising protection. The TSX Series delivers the performance and quality you need, in addition to the low sound, low energy, and exceptional user experience you deserve. Features and Benefits The drive for sample integrity and security ▪ Designed to safely store enzymes, reagents, pharmaceuticals, vaccines, biological and other commonly used laboratory and clinical materials requiring a tight temperature performance ▪ Unique V-drive technology is designed to detect usage patterns such as door openings when a higher compressor speed is needed and periods of stability where the compressor runs at a lower speed, saving energy without compromising protection ▪ Cold wall convection cooling for uniform and stable temperatures ▪ Easy to use microprocessor control with interior light, setpoint security and alarms ▪ Standard door locks provide comfort and assurance Enabling compliance ▪ Tested to GMP Clean Room Class A / ISO 5 & 6 (ISO EN 14644-1) with easy to clean surfaces support USP <797> and <800> hazardous drug compounding and other clean room environments ▪ Tested and certified to conform with the design and safety standards of UL 471, 61010, and CE Directive 2011/65/EU and 2015/863 Designed for an ergonomic and comfortable experience ▪ Ergonomically designed door handle with a soft-touch grip ▪ The controller is angled to help prevent neck strain ▪ Automatic pressure equalization port the enables fast reentry ▪ Easy to clean and adjust epoxy coated shelves ▪ Whisper quiet with a sound level of 52 dBA, enabling end users to work alongside the refrigerator without distraction ▪ Self-closing door with 90° stop to assist with inventory loads Verified sustainability ▪ US EPA ENERGY STAR Certified with up to 50% less energy usage than conventional refrigerant models* ▪ ACT Environmental Impact Factor Label Certified, providing third-party verification of the sustainable impacts of the product, its operations, and its end of life. ▪ Natural, R290 refrigerants and water-blown foam make the TSX Series compliant with EU F-GAS regulations, U.S. Environmental Protection Agency’s Significant New Alternatives Policy (SNAP), and other Global Environmental Regulations. ▪ Manufactured in an award-winning, zero-waste to landfill facility Ready for connectivity and monitoring ▪ Thermo ScientificTM DeviceLinkTM Connect ready, enabling you to have a connected experience with your unit so you always—and anywhere— know the safety of your samples and the performance of your refrigerator or freezer. ▪ Compatible with wireless monitoring systems and remote alarm contacts including our Thermo ScientificTM Smart-VueTM Pro wireless monitoring systems Make it your own ▪ Alternate Door swing configuration and door types ▪ Extra and Alternate wire baskets, shelves, and drawers ▪ Free-standing or factory-installed chart recorders ▪ E-Lock Adapter kits ▪ 4-20 milliamp transmitters and other remote alarm modules ▪ Specialty, regional, and country specific plugs Services and support ▪ Industry Leading 120-month compressor warranty (varies by country, please contact us for details) ▪ Optional Certificate of Calibration to an NIST (National Institute of Standards and Technology, formerly National Bureau of Standards) traceable instrument includes a model number and serial number certificate ▪ Optional Validation Testing Programs include in house and field-based temperature mapping and Installation Qualification (IQ) and Operation Qualification (OQ) programs ▪ Optional Factory Acceptance Test results including QC Test Log Sheets and QC Temperature Graphs

Thermo Fisher SCIENTIFIC

TSX Series High-Performance Lab Refrigerator

Thermo ScientificTM TSX Series high-performance lab refrigerators are designed with features that support sample protection and sustainability objectives for the storage of media, reagents, chemotherapy, pharmaceutical and other medical and laboratory-grade storage requiring 2° to 8°C. The Series’ V-drive technology is designed to provide temperature uniformity that continually adapts to user patterns, offering significant energy savings without compromising protection. Featuring over 450W of reserve refrigeration capacity, the TSX series has the power to protect your product from temperature swings as a result of frequent and prolonged door access, large product loads, and other activities that introduce hear to the cabinet. The TSX Series delivers the performance and quality you need, in addition to the low sound, low energy, and exceptional user experience you deserve. Features and Benefits The drive for sample integrity and security ▪ Designed to safely store media, reagents, chemotherapy, pharmaceutical and other medical and laboratory-grade products requiring a temperature range of 2°C to 8°C ▪ Unique V-drive technology is designed to detect usage patterns such as door openings when a higher compressor speed is needed and periods of stability where the compressor runs at a lower speed, saving energy without compromising protection ▪ Easy to use microprocessor control with interior light, setpoint security and alarms ▪ Standard door locks provide comfort and assurance Enabling compliance ▪ Tested to GMP Clean Room Class A / ISO 5 & 6 (ISO EN 14644-1) with easy to clean surfaces support USP <797> and <800> hazardous drug compounding and other clean room environments ▪ Tested and certified to conform with the design and safety standards of UL 471, 61010, and CE Directive 2011/65/EU and 2015/863 Designed for an ergonomic and comfortable experience ▪ Ergonomically designed door handle with a soft-touch grip ▪ The controller is angled to help prevent neck strain ▪ Convenient, easy to clean and adjustable epoxy coated full and half shelves ▪ Whisper quiet with a sound level of 52 dBA, enabling end users to work alongside the refrigerator without distraction ▪ Bright, LED interior lighting ▪ Self-closing multipaned glass or solid doors with 90° stop to assist with inventory loads Verified sustainability ▪ US EPA ENERGY STAR Certified with up to 40% less energy usage than conventional refrigerant models* ▪ ACT Environmental Impact Factor Label Certified, providing third-party verification of the sustainable impacts of the product, its operations, and its end of life. ** ▪ Natural, R290 refrigerants and water-blown foam make the TSX Series compliant with EU F-GAS regulations, U.S. Environmental Protection Agency’s Significant New Alternatives Policy (SNAP), and other Global Environmental Regulations. ▪ Manufactured in an award-winning, zero-waste to landfill facility Ready for connectivity and monitoring ▪ Thermo ScientificTM DeviceLinkTM Connect ready, enabling you to have a connected experience with your unit so you always—and anywhere— know the safety of your samples and the performance of your refrigerator or freezer. ▪ Compatible with wireless monitoring systems and remote alarm contacts including our Thermo ScientificTM Smart-VueTM Pro wireless monitoring systems Make it your own ▪ Alternate Door swing configuration and door types ▪ Extra and Alternate wire baskets, shelves, and drawers ▪ Free-standing or factory-installed chart recorders ▪ Stainless Steel interior finish ▪ E-Lock Adapter kits

Thermo Fisher SCIENTIFIC

Nicolet iS50 FTIR Spectrometer

Solve analytical challenges with ease using the Thermo ScientificTM NicoletTM iS50 FTIR Spectrometer, featuring purpose-built accessories and integrated software — making it an all-in-one materials analysis workstation. Designed to be highly flexible, the Nicolet iS50 FTIR Spectrometer can be upgraded from a simple FTIR bench to a fully-automated multi-spectral range system that can acquire spectra from far-infrared to visible. You can initiate novel ATR, Raman and NIR modules at the touch of a button, enabling access to these techniques without manually changing system components. Enquire Now The Nicolet iS50 FTIR Spectrometer gives you definitive answers when fast, easy workflows in your analytical laboratory are crucial. Features: ▪ Dual Source capable ▪ The PolarisTM long-life IR source ▪ Tungsten-Halogen white light source ▪ Three detectors for the main sample compartment ▪ High-resolution standard ▪ Validation wheel standard ▪ All gold optics standard (aluminum available) ▪ Full support for existing accessories ▪ Energy screens for high-res motorized (standard) ▪ Optional purge shutters ▪ Optional motorized filters ▪ Optional motorized polarizer ▪ Collimated or focused emission port Offerings you have come to know, like Smart Accessories, are augmented by the following optional modules: ▪ Built-in mid- and far-IR capable diamond ATR ▪ Automated Beamsplitter Exchanger (ABX) ▪ Sample compartment Raman accessory ▪ NIR module with Integrating Sphere and Fiber Optic connections ▪ TGA-IR accessory ▪ GC-IR module Find more information by visiting the technical library and viewing the spec sheet and brochure. ▪ Footprint – Base Only: 25 × 27 × 11in. (62.6 × 69.8 × 27.6cm) ▪ Weight – Base Only: 132 lb. (60kg) ▪ Footprint – Including ABX: 25 × 27 × 20in. (62.6 × 69.8 × 50.8cm) ▪ Weight – Base Only: Including ABX: 141 lb. (64kg) ▪ No footprint added for Raman and dedicated ATR ▪ Only 11in. (27.9cm) more with Nicolet iS50 NIR Module Recommended for: ▪ Polymers and Rubbers ▪ Forensics ▪ Pharmaceuticals ▪ Pigments/Paints/Inks ▪ Food/Flavors/Oils ▪ General Laboratories Cloud-enabled FTIR spectroscopy All Nicolet FTIR spectrometers now allow you to store, share and interpret spectral data anytime, anywhere and on any device. Researchers, lab technicians, educators and their students can all use their Thermo Fisher Connect account, powered by the Thermo Fisher Cloud, to gain easy access to their data with the OMNIC Anywhere App. ▪ Export, view and share data – view your Nicolet .spa spectral files, label spectral peaks, and correct spectral baseline all in the OMNIC Anywhere App on your PC, Apple computer, Android or iOS device ▪ Add more storage space – start with 10 GB of storage for free, and then scale up storage as needed for a nominal fee. You can store OMNIC .spa files as well as other files (e.g., report documents, .xls, etc.) to your Thermo Fisher Connect account ▪ Secure your data – Thermo Fisher Connect uses Amazon Web ServiceTM, the industry-leading security and data protection cloud-computing platform – so no lost or stolen data

Thermo Fisher SCIENTIFIC

AntarisTM II FT-NIR Analyzer

Easily implement laboratory-based FT-NIR performance in a ready-for-plant package using the Thermo ScientificTM AntarisTM II FT-NIR Analyzer. With industry-leading method transfer performance, the Antaris II FT-NIR Analyzer provides robust and reliable data collection for at-line, online and in-line analysis. You can customize an Antaris II FT-NIR Analyzer for specific applications or choose the Antaris II MDS Method Development Sampling System, which includes transmission, fiber-optic and integrating sphere diffuse reflection analysis all in one turnkey system. Features and Benefits The Antaris II FT-NIR Analyzer Allows You To: ▪ Analyze any sample type rapidly and accurately ▪ Make regulatory compliance (DQ, IQ, OQ and PQ) easy with the Thermo ScientificTM ValProTM Instrument Qualification Package ▪ Reproduce results regardless of configuration, maintenance, user or environment ▪ Achieve fast, precise and accurate measurements in the lab or in the plant Ordering Information: The Antaris II FT-NIR Analyzer is sold as a configured system designed to meet your specific needs. For more information, contact your Thermo Scientific Sales Representative. Recommended for: ▪ Solids ▪ Powders ▪ Grains ▪ Tablets ▪ Paste ▪ Gel ▪ Syrup ▪ Films ▪ Liquids

Thermo Fisher SCIENTIFIC

Finnpipette F2 Good Laboratory Pipetting (GLP) Kits

Access everything needed for pipetting in these all-inclusive kits. Thermo ScientificTM FinnpipetteTM F2 GLP (Good Laboratory Pipetting) Kits provide durable, high-performance Finnpipette F2 pipettes which offer maximum reliability and comfort. Built with tough PVDF components that stand up to harsh chemicals and the damaging effects of UV light, these variable volume pipettes are fully autoclavable without disassembling. Finnpipette F2: Proven reliable for long-term intensive use Features: ▪ Fully autoclavable for protection ▪ Tough PVDF components that stand up to harsh chemicals and the damaging effects of UV light ▪ Easy maintenance ▪ Color coded together with Finntips for easier recognition of compatible tips Kit 1 includes: ▪ Three Thermo Scientific Finnpipette F2 Pipettes from 1 to 1000 μL: ▪ 1-10 μL micro ▪ 10-100 μL ▪ 100-1000 μL ▪ Flex tips: 10 micro: 1 x 96; 200: 1 x 96; 1000: 1 x 96 ▪ F-stand ▪ Good Laboratory Pipetting Guide ▪ Reagent reservoir demo pack Kit 2 includes: ▪ Four Thermo Scientific Finnpipette F2 Pipettes from 0.2 to 1000 μL: ▪ 0.2-2 μL ▪ 2-20 μL univ ▪ 20-200 μL ▪ 100-1000 μL ▪ Flex tips: 10 micro: 1 x 96; 200: 2 x 96; 1000: 1 x 96 ▪ F-stand ▪ Good Laboratory Pipetting Guide ▪ Reagent reservoir demo pack Kit 3 includes: ▪ Three Thermo Scientific Finnpipette F2 Pipettes from 10 to 10,000 μL: ▪ 10-100 μL ▪ 100-1000 μL ▪ 1000-10,000 μL ▪ Flex tips: 200: 1 x 96; 1000: 1 x 96; FT 10 mL: 1 x 24 ▪ F-stand ▪ Good Laboratory Pipetting Guide ▪ Reagent reservoir demo pack Kit 4 includes: ▪ Three Thermo Scientific Finnpipette F2 Pipettes from 20 to 1000 μL: ▪ 2-20 μL ▪ 20-200 μL ▪ 100-1000 μL ▪ Flex tips: 200: 2 x 96; 1000: 1 x 96 ▪ F-stand ▪ Good Laboratory Pipetting Guide ▪ Reagent reservoir demo pack Ordering Information: The kit contains samples of Finntip Flex, the most advanced traditional tip offering very low attachment and ejection forces. The Good Laboratory Pipetting Guide contains helpful tips for pipetting including pipetting techniques, ergonomic considerations and how to select tips for best performance. Warranty: 5 years with web registration.

Thermo Fisher SCIENTIFIC

Finnpipette F2 Multichannel Pipettes

Use the Thermo ScientificTM FinnpipetteTM F2 Multichannel Pipette for highly demanding applications where robustness and durability are essential. With a sleek, rugged design, this pipette is built with PVDF components that stand up to harsh chemicals and the damaging effects of UV light. Fully autoclavable and available in 8-, 12- and 16-channel models with a selection of volume ranges. In the low volume models, the super blow-out function ensures accurate dispensing for even the lowest volumes. Finnpipette F2: Proven reliable for long-term intensive use Rugged and Durable Finnpipette F2 contains tough PVDF components that stand up to harsh chemicals and the damaging effects of UV light. Its rugged design withstands physical use without damage. Fully Autoclavable Decontamination of the Finnpipette F2 is simple as there is no need to disassemble the F2 for autoclaving, minimizing disruption and downtime. Maintenance is Easy Simply detach the tip cone for efficient daily maintenance or decontamination when not using an autoclave. Super Blow-out 150% increase in air boost to ensure efficient delivery of micro-volumes and prevent capillary action in 50μL models and below. Wide Selection of Finntip Pipette Tips Finntips are designed and manufactured expressly for Finnpipette models, enabling optimal performance, precision and accuracy. 5 Year Warranty With convenient online registration, and may vary by country.

Thermo Fisher SCIENTIFIC

Finnpipette F2 Variable Volume Pipettes

Meet the challenges of highly demanding applications where robustness and durability are essential with the sleek, rugged design of Thermo ScientificTM FinnpipetteTM F2 Variable Volume Pipettes. Built with tough PVDF components that stand up to harsh chemicals and the damaging effects of UV light, these variable volume pipettes are fully autoclavable without disassembling. They feature a wide selection of expressly designed tips for optimal performance, precision and accuracy. Finnpipette F2: Proven reliable for long-term intensive use Rugged and Durable Finnpipette F2 contains tough PVDF components that stand up to harsh chemicals and the damaging effects of UV light. Its rugged design withstands physical use without damage. Fully Autoclavable Decontamination of the Finnpipette F2 is simple as there is no need to disassemble the F2 for autoclaving, minimizing disruption and downtime. Maintenance is Easy Simply detach the tip cone for efficient daily maintenance or decontamination when not using an autoclave. Super Blow-out 150% increase in air boost to ensure efficient delivery of micro-volumes and prevent capillary action in 50μL models and below. Wide Selection of Finntip Pipette Tips Finntips are designed and manufactured expressly for Finnpipette models, enabling optimal performance, precision and accuracy. 5 Year Warranty With convenient online registration, and may vary by country.

VILBER LOURMAT

E-BOX

Gel Documentation The E-BOX is the ideal stand-alone imaging system for your gel documentation. It offers the best sensitivity and speed, and reaches the lowest limits of detection for your DNA, RNA and protein applications.

VILBER LOURMAT

FUSION

Chemiluminescence and Flourescence Chemiluminescence & Fluorescence systems are available as fully automated or manual version, with several ranges of CCD camera specifications and darkroom options. All systems are designed to be user friendly in operation which is supported by an intuitive user interface and software. The unrivaled FUSION is ideal for chemiluminescence, bioluminescence and UV fluorescence applications. Sensitivity is a key feature to detect a protein expressed at low levels. Broad linear dynamic range is necessary to compare weak and strong signals in the same image. The FUSION is a high-end ultrasensitive Scientific optical system, designed to extract the lowest level of detection from your protein. The Fusion systems’ cameras use the latest generation of sensors and semi-conductors. Combined with our unique build-in High Sensitivity Reading (HSR) technology and our unrivalled V.070 lens, the FUSION is the most sensitive system and the best for publication, quantification and documentation grade imaging.

VILBER LOURMAT

NEWTON 7.0

Sea and Animal Plant Imaging The NEWTON 7.0 is a highly sensitive optical imaging system dedicated to the visualization of in vivo, in vitro and ex vivo applications. Various bioluminescent reporters like firefly luciferase and many fluorescent molecular reagents can be used to visualize and track tumor, disease or inflammation development, target molecules to nanoparticles or follow biodistribution and pharmacokinetics studies within living animals in a noninvasive manner.

VILBER LOURMAT

QUANTUM

Gel Documentation The QUANTUM combines unrivaled ease of use and gel imaging performance. Advanced technologies inside, outstanding ease of use outside. Our latest innovations make the E-BOX and the QUANTUM the ideal systems for publication, quantification and documentation grade imaging.

Waters

Alliance HPLC System

Defined by dependability – today, and in the future ▪ Time-tested, flexible, and reliable workhorse for your HPLC separations ▪ Integrated solvent and sample management with consistent system-to-system performance and high reproducibility ▪ A history of continued system improvements ensures the hightest in HPLC performance ▪ Simplify your daily LC system start-up with advanced software functionality Features and Benefits ▪ Quaternary solvent blending supports isocratic and gradient applications with 11 unique gradient profile curves. Blend up to 4 solvents in any proportion with Auto-Blend Technology. Compatible with a wide range of solvent types to support reversed-phase, normal-phase, GPC, SEC, and IEX application. ▪ Advanced solvent delivery capabilities. Serial flow path with pulse-free solvent delivery without the use of dampeners. Online solvent degassing and automated solvent compressibility for accurate flow. Integrated seal wash for robustness operation with all solvent types is standard. ▪ Up to 120 vials housed in an optional, temperature-controlled environment. Active and user programmable needle wash for low carryover. Variable injection volumes from 0.1 to 100 uL standard, and up to 2 mL optional. Supports STAT samples and auto- addition. ▪ Optional column heating or heating/cooling. Get the flexibility of running multiple methods on demand with optional column switching. ▪ Quaternary solvent blending supports isocratic and gradient applications with 11 unique gradient profile curves. Blend up to 4 solvents in any proportion with Auto-Blend Technology. Compatible with a wide range of solvent types to support reversed-phase, normal-phase, GPC, SEC, and IEX application. ▪ Advanced solvent delivery capabilities. Serial flow path with pulse-free solvent delivery without the use of dampeners. Online solvent degassing and automated solvent compressibility for accurate flow. Integrated seal wash for robustness operation with all solvent types is standard. ▪ Up to 120 vials housed in an optional, temperature-controlled environment. Active and user programmable needle wash for low carryover. Variable injection volumes from 0.1 to 100 uL standard, and up to 2 mL optional. Supports STAT samples and auto- addition. ▪ Optional column heating or heating/cooling. Get the flexibility of running multiple methods on demand with optional column switching.

Waters

ARC HPLC System

Accurate analysis for all Ever-evolving regulations are impacting LC method approaches for product quality control and beyond. Count on the Arc HPLC System for high-efficiency separations and quality data to help meet your regulatory requirements with confidence. With the Arc HPLC, you can easily replicate and improve the performance of existing LC methods without compromising data quality, eliminating the burdens of older, less efficient LC systems for routine use. Rugged and dependable, Arc HPLC delivers the ideal balance of performance and value for right-the-first-time analysis and trusted test results: ▪ Enhance performance without redeveloping your method ▪ Run methods with greater robustness over traditional HPLCs ▪ Easily replicate, adjust, and enhance existing HPLC methods with low analyte carryover, high injection precision, and high back pressure tolerance ▪ Seamlessly receive transferred methods from other HPLC platforms, preserving analyte retention time and reproducibility of your analysis ▪ Support compliance with Empower Chromatography Data System (CDS), the gold standard, compliant-ready software that facilitates data review, eliminates burdensome compliance documentation, and improves the overall quality of laboratory data Features and Benefits ▪ High Performance Analytical Detectors A wide range of high performance detection capabilities, optimized to support the diversity of applications. Includes photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, conductivity, and mass detection. ▪ Gradient SmartStart Adjust the injection relative to the gradient start to emulate other HPLC systems’ dwell volumes, without the need to alter the gradient table. Successfully transfer most methods in just two injections. ▪ Quaternary Solvent Management Precise and accurate blending of up to four solvents with automated solvent compressibility compensation. Increase solvent flexibility with an optional, integrated solvent select valve, providing access to six additional solvents. ▪ Auto•Blend PlusTM technology Program gradients directly in terms of pH and ionic strength to minimize manual mobile phase preparation and reduce potential for human error in routine analysis. ▪ Column Technology Heating and cooling that supports columns up to 300 mm in a stable temperature environment for method repeatability from lab-to-lab. Optional and integrated column switching for up to three columns provides unattended column changeover. Simplify method screening and easily switch back and forth to support multiple methods on one system. ▪ Negligible Carryover Advanced flow-through needle design minimizes carryover by continuously cleansing the needle during run. User-configurable wash settings provide capability to address even ‘sticky’ compounds to help ensure a clean analysis of the current target sample. Designed for Robustness Integrated solvent degassing, seal wash, and fluidic path designed to reduce clogging associated with high salt content buffers for maximum uptime. Holistic Offerings Benefit from an integrated offering of industry-leading columns, chemistry and software solutions to meet the needs of virtually every HPLC application. ▪ Columns: The perfect pairing for high-quality separations ▪ Informatics: Get more from your data for more confident decisions ▪ Global Services: Committed to your success

Waters

ACQUITY Advanced Polymer Chromatography System

The Next Era in Polymer Separation ▪ Highest-resolution, size-based separations for chromatographic polymer characterization ▪ Improve data consistency and quality by enabling fast, daily calibration ▪ Automate method development with advanced system technologies ▪ Get more information about your polymer, faster than before Features and Benefits ▪ Accelerate innovation through high-resolution insight into your polymer separations on sub 3- μm, rigid, high-pore volume ACQUITY APC columns paired with the ultra-low system dispersion of the ACQUITY APC System. ▪ Optimize method development via rapid and automated solvent switching and aggressive solvent compatibility, which supports the harsh separation conditions associated with polymer analyses. ▪ Increase analytical scope and laboratory efficiency by leveraging one system to perform multiple applications, including basic LC, gradient, isocratic, reverse-phase and GPC. ▪ Gain more insight into your polymer samples through broad compatibility with a wide range of detection techniques and third-party advanced detectors, including refractive index, UV/visible, photodiode array, or evaporative light scattering, and compatibility with advanced techniques like multi-angle light scattering and viscometry. ▪ Reduce laboratory turnaround times for polymer samples by getting answers to your development labs, your manufacturing operations teams, and your customers 5-20x faster than traditional SEC/GPC. ▪ Simplify and optimize column bank calibration through standards that are matched to column bank MW ranges. ▪ Versatile column management allows you to automatically select up to two banks of ACQUITY APC columns and up to two banks of traditional GPC columns – all housed in a stable, temperature-controlled environment. ▪ Precise flow delivery of the isocratic solvent manager ensures accurate MW data, day after day.

Waters

ACQUITY UPC2 System

The ease of reversed phase meets the power of normal phase. With the ACQUITY UPC2 System, the orthogonal capability of normal-phase LC has been elevated to a mainstream technique: Convergence Chromatography. ▪ The chromatographic principles and selectivity of normal-phase LC ▪ The ease-of-use and method development simplicity of reversed-phase LC ▪ The use of gradients across the widest polarity range ▪ Chiral and achiral separations in one system, with unequaled speed and confidence Features and Benefits Bringing ease-of-use to normal-phase LC By providing the ability to precisely vary mobile phase strength, pressure, and temperature, the Waters ACQUITY UPC2 System gives scientists the power to better control the retention of analytes for separating, detecting, and quantifying structural analogs, isomers, and enantiomeric and diasteriomeric mixtures. The world’s first convergence chromatography system Unique in its capabilities, the pioneering ACQUITY UPC2 System delivers what the rest of the industry never could – a system, based on the principles of normal-phase LC, with the ease-of-use of reversed-phase LC, and purposefully built for analytical performance, placing convergence chromatography atop the list of separations tools in the kit of all analytical chemists. Retention mechanisms and orthogonality to RPLC Harnessing what’s now known as convergence chromatography, an evolution of the traditional SFC technique, the ACQUITY UPC2 System has the power to create selective separations of structurally similar chiral and achiral compounds. The miscibility of CO2with a wide range of polar and non-polar organic solvents has made the liquid CO2-based mobile phase versatile enough to separate a much wider range of compounds than reversed-phase LC, especially for mixtures containing polar compounds. Not only can CO2-based solvents be used with both polar and non-polar stationary phases, but chromatography can be influenced by modulating solvent gradients with a much wider choice of columns using the same mass spectrometry-compatible co-solvents. Being orthogonal to reversed-phase LC, UPC2 separations often show an inverse order of elution among groups of analytes. In combination with various detection techniques, this orthogonality is valuable for confirming analyte identity in complex matrices.

Waters

ACQUITY Arc System

HPLC and UHPLC method compatibility at the flip of a switch The ACQUITY Arc System is a quaternary-based, modern LC system for scientists working with established methods who are looking for the versatility and robustness required to bridge the gap between HPLC and UPLC while continuing to support validated assays. ▪ Regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument ▪ Get mass detection, without changing the way you work, with the ACQUITY QDa Detector ▪ Deploy the benefits of 2.x μm particle columns to boost the chromatographic performance of your methods ▪ On-demand mobile phase creation with Auto●Blend Plus Technology, eliminating the cumbersome and error-prone approach of manual preparation

Waters

Arc Premier System

See clearly and consistently, with confidence. Today’s scientists and lab managers need to confidently produce the most accurate, reliable and reproducible data. The Arc Premier System produces correct, robust results from the very first injection, reliably and easily. The Arc Premier System features the new, innovative technology of MaxPeak High Performance Surfaces (HPS) Technology, which effectively reduces non-specific adsorption due to metal interactions, without complicated mobile phases or laborious methods. The Arc Premier System sharpens chromatographic peaks for metal-sensitive compounds by eliminating secondary interactions from metals, resulting in: ▪ Improved compliance from higher quality data ▪ Faster, more reproducible, and accurate data integration ▪ Shorter time from sample to result, without conditioning

Waters

ACQUITY Premier System

▪ Maximizing the sensitivity, repeatability, and robustness of your LC and LC-MS applications is critical. The ACQUITY Premier System is the next evolution of the Performance LC System which include the ACQUITY UPLC H-Class PLUS and ACQUITY UPLC I-Class PLUS Systems. Along with the reliability, ruggedness, high quality, and configuration flexibility you expect from the ACQUITY UPLC PLUS Series, the ACQUITY Premier System delivers a step change in chromatographic performance, lab efficiency, and risk control. ▪ The ACQUITY Premier System features MaxPeak High Performance Surfaces (HPS) Technology, which offers improvements in separation and detection of metal-sensitive analytes, enabling you to minimize the risk of undetected analytes – for increased efficiency and confidence in your results. Overview ▪ Minimize risk of undetected analytes with MaxPeak High Performance Surfaces (HPS) Technology ▪ Decrease time-to-result and increase overall efficiency by eliminating time-consuming system and column passivation ▪ Improve peak shape and reproducibility for the most challenging metal-sensitive compounds ▪ Achieve high-precision injections with direct inject sampling ▪ Reduce time on method development ▪ Multi-software platform support options with Empower, MassLynx, and UNIFI

Waters

ACQUITY UPLC H-Class PLUS System

Performance that advances your lab ▪ Improve laboratory productivity by transitioning methods to UPLC Technology ▪ Improve the characterization of your most complex samples through enhanced resolution ▪ Leverage advanced tools that simplify and streamline your method development workflow ▪ Improve precision with state-of-the-art high pressure binary or quaternary solvent blending ▪ Increase the analytical value of your samples by leveraging optical and mass information ▪ Match the need of your laboratory through support of your existing HPLC, UHPLC, and UPLC methods Features and Benefits ▪ Get the flexibility of multi-solvent blending with the Quaternary Solvent Manager (QSM), and blend four solvents in any combination or proportion. Expand to up to nine solvents with the optional and integrated solvent-select valve for even greater flexibility. Automated solvent compressibility allows you to run any solvent in any combination without loss in accuracy or precision. ▪ Deliver precise and accurate binary solvent blending with the Binary Solvent Manager (BSM) at pressures up to 15,000 psi. Two integrated solvent select valves provide access to a total of four solvents. Automated solvent compressibility, integrated solvent degassing, and programmable seal wash maximize flow accuracy, precision, and reliability. ▪ High-precision injections with direct inject sampling. The needle-in-flow path design ensures an accurate needle seal at high pressure. Injection volumes from 0.1 μL up to 1 mL are supported. Ultra-low carryover is managed through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers. ▪ Accurate temperature control across the entire column. Configurable for 1 to 6 columns, each housed in individual temperature controlled zones with active pre-heating and a temperature range of 4 to 90 °C. ▪ Low-dispersion detection capabilities. The ACQUITY UPLC H-Class PLUS System is the only LC system in the market with a wide range of detectors that have been optimized for true UPLC performance. Minimizing dispersion and optimizing the electronics and optical paths for the narrow UPLC peaks yields the highest sensitivity and repeatability with the most accurate quantification. ▪ Significantly reduce the time you spend in the prep lab by automating the formulation of mobile phases at specific pH and ionic strength from reservoirs of pure solvents or concentrated stock solutions using Auto•Blend Plus Technology, available with the ACQUITY UPLC H-Class PLUS Quaternary System. Compatible with reversed phase, IEX, and SEC, this technology makes routine analyses easier to manage and execute and streamlines method development and method robustness testing by allowing you to test even the smallest changes in pH and ionic strength without needing to make each individual buffer. ▪ Automatically manage gradient start time and pre-injection steps in parallel with SmartStart Technology. This allows you to compensate for system volume differences when transferring methods between different LC systems or to minimize inject-to-inject cycle times for high throughput applications. ▪ Gradient SmartStart Easily adjusts for system volume differences when transferring methods from an alternative LC system without alteration to the method table. ▪ Supported in Empower, Masslynx, UNIFI, and several 3rd party software packages.

Waters

ACQUITY UPLC I-Class PLUS System

Complex challenges, solved With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS provides new possibilities of maximizing the resolution and sensitivity of your methods; enhancing the characterization of your samples, while improving productivity to advance the science of your laboratory. ▪ Highly efficient, rapid separations are facilitated by industry-leading ultra-low dispersion and delay volume. ▪ Ultra-efficient, narrow peaks enhance the sensitivity of any mass spectrometer to simplify the characterization of the most complex samples. Features and Benefits ▪ Delivers precise and accurate binary solvent blending at pressures up to 18,000 psi. Two integrated solvent select valves provide access to a total of four solvents. Automated solvent compressibility, integrated solvent degassing, and programmable seal wash maximize flow accuracy, precision and reliability. ▪ Sample injection versatility, depending upon your application. Select a needle-in-flow path injector to maximize the injection volume range from 0.1 to 1000 μL. Select a loop-based injector to achieve the lowest inject-to-inject cycle times. Ultra-low carryover is managed through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers. ▪ Ideally suited for high-throughput applications with the addition of the sample organizer, expanding the capacity to up to 19 plates/7,296 samples. ▪ Accurate temperature across the entire column provided by advanced column management. Active pre-heating ensures accurate temperature across the entire column with a temperature range of 4 to 90 °C. Configurable in a single or dual column configuration with automated column switching, or optional two-position valves can be installed to support multi-dimensional (2D) chromatography. ▪ Wide range of low-dispersion detection capabilities that have been optimized for true UPLC performance by minimizing dispersion and optimizing the electronics and optical paths for accurate quantification of the narrow UPLC peaks with the highest sensitivity and repeatability. ▪ Improves the performance of any mass spectrometer with the highest chromatographic resolution which minimizes interference from co-elutions. ▪ Compliance ready. Qualification of laboratory instrumentation is an integral part of compliance with regulatory and quality standards such as GMP, GLP, ISO 17025, USP <1058>, and others. The ACQUITY UPLC I-Class PLUS System supports Waters Empower-based automated system qualification tool (SQT), which minimizes the time and cost associated with annual qualification. ▪ Supported in Empower, Masslynx, UNIFI, and several 3rd party software packages.

Waters

ACQUITY UPLC M-Class System

LET YOUR LC INLET DO THE WORK FOR YOUR NANO- TO MICROSCALE SEPARATIONS ▪ System of choice for sample-limited applications in proteomics and biomarker discovery ▪ Higher sensitivity for any MS ▪ Maximum amount of data from any sample ▪ Less sample preparation volume and cost ▪ Reduced solvent consumption ▪ Increased dynamic range ▪ Flexible configurations for HDX technology, 2D, and UV detection Features and Benefits ▪ The analysis you’ve always desired for nano- to microscale separations. The ACQUITY UPLC M-Class System delivers the most robust, reliable, and highest quality nano- to microscale UPLC separations to every laboratory performing LC/MS analyses. With unprecedented usability, the ACQUITY UPLC M-Class System enables laboratories to succeed in analyzing compounds that are severely limited in amount or availability, even amid a complex matrix over several orders of magnitude. Confidently achieve your laboratory goals with high-efficiency ACQUITY UPLC M-Class Columns ranging from 75 μm to 1 mm I.D. by using complementary mass spectrometry to support our full range of column I.D.’s, or run 300 μm to 1 mm I.D. columns with optical detection. The system also offers a range of flexible configurations for HDX technology, UV detection, and 2D analysis. ▪ Expand the dynamic range of your analysis with 2D separations. The ACQUITY UPLC M-Class System has streamlined 2D-LC separations with a highly intuitive menu-driven method setup, standardized separation chemistries, and intelligent valve operation. Expanding on the use of a novel 2D reversed phase/reversed phase (RP/RP) approach, where the first dimension is run at pH 10 and the second at pH 2, grants the ability to robustly increase sample throughput with MS-compatible eluents. ▪ Your inlet to MS. The ACQUITY UPLC M-Class System expands the performance of any nano- to microscale MS analysis. It increases the linear dynamic range of your analysis, resulting in better MS analyses by DDA or MSE. The direct(non split) automatic solvent flow control algorithms of the ACQUITY UPLC M-Class System provide pulse-less flow for increased retention time reproducibility. Sample integrity is maintained due the ACQUITY UPLC M-Class System’s non-reactive surfaces. New drivers for MassLynx Software integrate the system seamlessly into your existing workflows. Monitor protein conformation with HDX technology. The ACQUITY UPLC M-Class System can quantify small changes in protein conformation by extending its pressure range to enable a higher efficiency separation. The system allows for manual sample injection and integrates the steps of HDX from digestion and separation still integrates all the steps of HDX from sample prep to actual sequence determination, D2 uptake curves, and comparison plots with Waters, interactive, highly innovative DynamXTM HDX Data Analysis Software. HDX data has become an enabling technology that can be used to make business decisions about: ▪ Drug candidate binding to a protein target ▪ Biopharmaceutical product development ▪ Protein-protein interactions ▪ Intellectual Property

Waters

ACQUITY QDa Mass Detector

Press On to Bring the Power of Mass Detection to Your Lab With great detection power comes great possibility – Minimize the risk of unexpected coelutions or components and confirm trace components with the analytical confidence of mass detection. Enhance the analytical value and productivity of each analysis. ▪ Intuitive operation ▪ More information from every sample ▪ Effortless integration ▪ Increased efficiency ▪ Resolving complexity Intuitive Operation ACQUITY QDa is as intuitive as an optical detector, with the robustness to handle all of your analyses. Working in harmony with your chromatography, it is pre-optimized to work with your samples, without the sample-specific or user adjustments typical of traditional mass spectrometers. For the first time, any analytical scientist can consistently generate the highest quality mass spectral data, routinely without the need for any special training or expertise thus eliminating any need to contract out and wait for results from specialist analytical service laboratories. Features and Benefits Effortless integration The ACQUITY QDa Detector is compatible with all Waters ACQUITY UPLC, ACQUITY UPC2, Alliance HPLC, and purification LC and SFC systems. The ACQUITY QDa Mass Detector is complementary to your current Waters optical detectors including ACQUITY UPLC PDA, TUV, or FLR, or ACQUITY UPC2 PDA optical detectors. The mass spectral information combines seamlessly into the same workflow, routinely giving you more complete characterization of your separation. Process, interpret, visualize, and compare the most complex data, and turn it into meaningful information quickly and simply. The ACQUITY QDa Detector is fully compatible with Empower Software, our industry-leading chromatography data software platform. With integrated optical and mass detector data processing workflows, you can also interrogate mass spectral data in the same way and same workflow as you do PDA data. The ACQUITY QDa Detector is also fully compatible with MassLynx Software and its suite of Application Managers. Increased efficiency The only mass detector that integrates with and even fits on top of your instrument stack. Using less bench space, less floor space and less energy than a traditional mass spectrometer, it fits easily within your existing laboratory set up as part of your regular workflow. Even routine maintenance is minimized, maximizing your uptime.

Waters

RADIAN ASAP Direct Mass Detector

The Power of Knowing Now Whether you are looking to improve your drug discovery cycle, expand your client services, or simply become more competitive in your turnaround times; integrating direct MS analysis can drive multiple system-wide efficiencies helping to achieve your operational goals. Combining flexibility, ease of operation and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more. ▪ Simple operation and data interpretation ▪ Minimal sample preparation ▪ No separation required ▪ Real-time results and classification. Compact Without Compromise The RADIAN ASAP is a novel, dedicated direct analysis system specifically designed for rapid, easy and low-cost analysis of liquids and solids. Engineered using proven and robust single quadrupole mass spectrometry technology combined with the Atmospheric Pressure Solids Analysis Probe (ASAP), the RADIAN ASAP delivers quality and ease of use in a compact footprint. The single quadrupole mass detector provides high quality mass spectral data, without the need for any special training or expertise thus eliminating any need to contract out and wait for results from specialist analytical service laboratories. Applications Forensics Rapid triage of seized drug materials Knowing now with RADIAN ASAP and LiveID ensures crime labs can quickly screen samples against a library of known compounds for rapid, confident identification of illicit drugs. The sensitivity and selectivity of mass spectrometry provides confidence in detecting drugs with an easy, efficient triage workflow. Food & Environmental Assess food integrity The threat posed by food fraud has created additional demands on both the food industry and regulators to protect food consumers and maintain brand reputation. Knowing now with RADIAN ASAP and LiveID offers a powerful combination of mass spectrometry and chemometric modelling, which allows users to easily and efficiently screen samples and make quicker decisions. Chemicals and Materials Fast chemical analysis for improved formulation testing Knowing now with RADIAN ASAP and IonLynx supports QC and Development Labs in the chemical industry to reduce costs and increase efficiencies. Workflows, such as fast chemical analysis for improved formulation testing or material release testing, can be streamlined. Features including thermal gradient analysis are ideal for complex samples commonly seen in the chemical industry. Pharma Discovery reaction monitoring The demand to accelerate the drug discovery and development process has never been higher. Knowing now with RADIAN ASAP provides synthetic chemists easy access to mass spectral data for near instantaneous assessment of reaction progress and identification of purification fractions, increasing lab efficiency. LiveID – Authenticity Testing For customers investigating the authenticity, adulteration and quality of food or raw materials, LiveID uses statistical models to classify samples. First, authentic or verified samples are used to create and validate a statistical model. The validated model can then be used with test samples and generate live classifications. The output is a simple to interpret yes/no answer. LiveID – Library Matching LiveID is also capable of real time library matching workflows, where the software matches all compounds in the library against each sample analyzed, giving a score out of 1000, where values close to 1000 indicate it is likely the compound of interest is in the sample; lower scores indicate it is unlikely to be present in the sample Automated data processing and reporting OpenLynx processing provides user customizable processing capabilities to generate automated mass confirmation reports in either pdf, printed or browser format. IonLynx allows users to determine levels and relative ratios of analytes of interest in complex samples to aid decision making in QC and formulation monitoring. IonLynx provides automated processing and reporting of non-chromatographic data sets, such as those generated by RADIAN ASAP.