Microfuge 16

Perform a wide variety of routine sample processes and micro-volume protocols with the ultra-compact Beckman Coulter Microfuge® 16. This microprocessor-controlled mini benchtop centrifuge generates centrifugal forces required for a wide variety of applications. ▪ 14,800 RPM ▪ 16,163 x g Fast Micro-Centrifugation ▪ Maintenance-free rotors spin up to 14,800 rpm (16,163 x g) ▪ Large bright display with simple push button key entry and automatic lid release at run completion Maximize Productivity ▪ Reduces process time with fast acceleration and deceleration rates ▪ Choice of pulse, timed or continuous runs for added flexibility Ensure Safety ▪ The Microfuge 16 features a brushless induction drive, safety auto-lock closure system ▪ Unique, air-cooled rotor bowl for years of safe, high-performing operation Ultra-Compact Design ▪ The instrument features a compact footprint, measuring at 8.9 by 10.5 inches ▪ Accommodates a wide array of microcentrifuge tubes from 0.2 to 2.2 mL with a choice of standard or soft start/stop programs

Microfuge 20

Speed and versatility in a compact footprint. Fast, cool and versatile, the high-performance Microfuge® 20 Series are precisely designed to meet a wide variety of application needs including, ▪ Nucleic acid and protein preparation ▪ Pelleting, extractions ▪ Purifications ▪ Concentrations ▪ Phase separations and receptor binding ▪ Rapid sedimentation of protein precipitates, particulates and cell debris. Paired with Beckman Coulter Microfuge Series rotors, this mini-centrifuge series offers you all the flexibility you need for your separation protocols. ▪ 15,000 RPM ▪ 20,627 x g Meet your Application Needs ▪ Available in refrigerated and non-refrigerated designs ▪ Four different rotor options from for ultimate flexibility ▪ Optional BioCertified rotor for safe processing of hazardous samples Increased Speed and Capacity ▪ Fast sample processing at maximum speeds of up to 15,000 rpm (20,627 x g) ▪ Spin more samples per run with a maximum capacity of 36 x 1.5/2.0 mL tubes An Intuitive Addition to your Lab ▪ Efficient and easy-to-use interface displays both speed (rpm) and RCF (xg) ▪ Reduced setup time with user-defined programs for common lab protocols ▪ Lower total cost-of-ownership with increased energy efficiency ▪ Increased Safety Measurements ▪ Safely process samples with optional BioCertified* FA361.5 fixed angle rotor

Microfuge 20R

Speed and versatility in a compact footprint. Fast, cool and versatile, the high-performance Microfuge® 20R Series are precisely designed to meet a wide variety of application needs including, ▪ Refrigerated ▪ Nucleic acid and protein preparation ▪ Pelleting, extractions ▪ Purifications ▪ Concentrations ▪ Phase separations and receptor binding ▪ Rapid sedimentation of protein precipitates, particulates and cell debris. Paired with Beckman Coulter Microfuge Series rotors, this mini-centrifuge series offers you all the flexibility you need for your separation protocols. ▪ 15,000 RPM ▪ 20,627 x g Meet your Application Needs ▪ Available in refrigerated and non-refrigerated designs ▪ Four different rotor options from for ultimate flexibility ▪ Optional BioCertified rotor for safe processing of hazardous samples Increased Speed and Capacity ▪ Fast sample processing at maximum speeds of up to 15,000 rpm (20,627 x g) ▪ Spin more samples per run with a maximum capacity of 36 x 1.5/2.0 mL tubes An Intuitive Addition to your Lab ▪ Efficient and easy-to-use interface displays both speed (rpm) and RCF (xg) ▪ Reduced setup time with user-defined programs for common lab protocols ▪ Lower total cost-of-ownership with increased energy efficiency Increased Safety Measurements ▪ Safely process samples with optional BioCertified* FA361.5 fixed angle rotor

Airfuge Air-Driven

Process lipemic samples with the Airfuge Air Driven Ultracentrifuge The Airfuge® Air-Driven ultracentrifuge offers a simple, rapid method for removing chylomicrons (fat particles in lipemic samples) for accurate lipemic clarification results. Lipemic samples can be cleaned in 10 minutes, eliminating the need for time-consuming send-outs. Increased Efficiency ▪ Reaches max speed in 30 seconds or less ▪ Combination of high g-forces and short path lengths ▪ Decelerates smoothly to keep contents separated Enhanced Versatility ▪ Variety of rotors to support pelleting of nearly all materials done in a full-size centrifuge ▪ Rapid clarification of lipemic blood samples Small Volume Processing ▪ No need to dilute precious samples ▪ 100uL to 7mL processing Lab Space Optimization ▪ Sub-compact centrifuge minimizes the space required bench space for centrifugation

Optima MAX-TL

Reach the speeds you need for your separation demands with this compact, quiet and highly efficient tabletop ultracentrifuge. Packed with advanced technology yet simple to operate, the OptimaTM MAX-TL runs on multi-lingual software offering labs around the world greater efficiency and confidence in results. For added versatility, the MAX-TL ultracentrifuge is compatible with the existing Beckman Coulter TL-Series rotors and labware. System Design ▪ Designed as a total system for better efficiency ▪ Rotors and labware have been manufactured and tested based on unique characteristics ▪ Interplay of dynamics to ensure optimal performance and safety Enhanced Safety ▪ Fits in standard biosafety hoods ▪ BioSafe optional dual PALL® Pharmaceutical Grade Sterilizing filters Energy Efficient ▪ Optional pharmaceutical grade sterilizing filter offers multi-layered approach ▪ BioSafetyFully compatible with existing TL-series rotors and labware User-Friendly, Multilingual Interface ▪ Full color LCD touchscreen display ▪ Allows for large icons for easy selection ▪ Touchscreen works with many glove types ▪ 9 different languages available for the intuitive interface (most in industry)

Optima MAX-XP Ultracentrifuge

The OptimaTM MAX-XP tabletop ultracentrifuge is a power-packed solution that delivers fast, efficient separations from samples as small as 175 μL up to 32.4 ml and at speeds of up to 150,000 RPM and more than 1,000,000 x g. ▪ Advanced software with rigorous electronic record keeping including password-controlled access and complete audit trail documentation ▪ Convenient touch-screen controls and easy-to-view display for gauging real-time speed, time and temperature ▪ Four unique tube designs for unparalleled productivity across a wide range of applications ▪ Features a proprietary multi-level approach to biosafety offering reliable protection Track Detail Usage History ▪ Security and tracking features manage your rotor life by serial number. ▪ Password protection and electronic signatures help you maintain chain of custody and compliance. Receive Diagnostic Alerts via Email ▪ Remote monitoring and control enables you to start, stop, and monitor from your computer, smart phone, or tablet. Enhanced Safety ▪ Fits in standard biosafety hood ▪ BioSafe optional dual PALL® Pharmaceutical Grade Sterilizing Filters User-Friendly, Multilingual Interface ▪ Full color LCD touchscreen display ▪ Allows for large icons for easy selection ▪ Touchscreen works with many glove types ▪ 9 different languages available for the intuitive interface (most in industry)

Optima XPN Ultracentrifuge

The OptimaTM XPN is the premier ultracentrifuge. With networking capability and customizable security and tracking features to ensure chain of custody and compliance, the Optima XPN offers multi-layered BioSafety* features for a safe and productive work environment. ▪ Equipped with the innovative eXpert simulation software ▪ Available in 100k, 90k, and 80k RPM configurations ▪ Compatible with extensive rotor and labware options ▪ Backed by unparalleled service program options Optimize protocols before running Quickly perform common calculations and conversions with proprietary software to optimize protocols, save time, and save samples. Receive diagnostic alerts via email Remote monitoring and control enables you to start, stop, and monitor from your computer, smart phone, or tablet. Track detail usage history Security and tracking features manage your rotor life by serial number. Password protection and electronic signatures help you maintain chain of custody and compliance. Enhanced Safety ▪ Dynamic Rotor Inertia Check (DRIC) ▪ Rotor overspeed disc ▪ Real and simulated testing ▪ BioSafe optional dual PALL® Pharmaceutical Grade Sterilizing Filters

Optima XE Ultracentrifuge

With all the features you expect, along with many advanced functions you won’t find anywhere else, the OptimaTM XE simplifies use while offering secure loading for efficient, worry-free separations. Designed as a total system, Optima instruments, rotors and labware are designed, manufactured and tested as an integrated system for optimal performance and safety. The Optima XE features: ▪ Intelligent user interface ▪ Multi-layered biosafety features ▪ Efficient energy use Energy Efficient Technology ▪ Maintains runs during power fluctuations ▪ Run Recovery feature allows to continue a run once the power is restored ▪ Regenerative braking and low idle power equates to lower power consumption from the centrifuge Easy to Use Interface ▪ 38.1cm (15”) LCD touchscreen display ▪ Allows for large icons for easy selection ▪ Status can be seen from across lab ▪ Touchscreen works with many glove types ▪ 9 different languages available for the intuitive interface (most in industry) Enhanced Safety ▪ Rotor overspeed disc ▪ Dynamic Rotor Inertia Check (DRIC) ▪ BioSafe optional dual PALL® Pharmaceutical-Grade Sterilizing Filters Quiet Drive Technology ▪ Designed for the lowest drive noise, which equates to less than 51 dBA during operation.

CytoFLEX Flow Cytometer

The CytoFLEX Flow Cytometer, the first introduction to the CytoFLEX Platform, provides the performance you need in an easy to use system allowing you to focus on the science, not the instrumentation. Its superior sensitivity and resolution throughout all configurations give it the edge over other cytometry systems four times its size. All instruments in the platform utilize CytExpert for CytoFLEX Acquisition and Analysis Software. Key Features ▪ Up to three lasers (Violet-Blue-Red Series) and 13 fluorecent detectors or as few as four, additional channels in the future ▪ Includes 13 band pass filters: 450/45, 525/40 (2), 585/42, 610/20 (2), 660/10 (2), 690/50, 712/25, 780/60 (3) ▪ For higher throughput applications an optional plate loader module is available and for use in regulated environments the software contains tools for 21 CFR Part 11 compliance ▪ Exquisite Sensitivity Key Features -Unique collection of innovative technologies provide exceptional detection capabilities -Large dynamic range to resolve dim and bright populations in the same sample -Use violet side scatter to detect nanoparticles ▪ Platform Versatility -Purchase the number of parameters needed now -Add more detection channels by purchasing an activation key -Includes full complement of repositionable bandpass filters, non-standard filters also available for even more flexibility ▪ Low Maintenance -Lasers, steering optics and flow cell are all mounted onto a vibration isolated table, maintaining optical alignment -Low pressure fluidics system -Preventive Maintenance can be completed by the user, no service visit required ▪ Automation Enabled -Optional 96-well plate sample loader module -API (Application Programming Interface) allows external software to control the instrument -For automated sample processing and data acquisition integrate with the Biomek i-Series Instrument

CytoFLEX LX Flow Cytometer

The CytoFLEX LX Flow Cytometer is an expansion of the CytoFLEX Platform. This model expands research possibilities with up to six lasers and 21 color parameters. Six spatially separated lasers allows panels to be spread across the spectrum reducing cross talk and spectral overlap. All instruments in the platform utilize CytExpert for CytoFLEX Acquisition and Analysis Software. ▪ Up to six lasers (488 nm, 638 nm, 405 nm, 561 nm, 375 nm, 808 nm ) and 21 fluorescent detectors ▪ Two series are available, UV-Violet-blue-Yellow Green-Red-IR (U-V-B-Y-R-I) and Near UV-Violet-Blue-Yellow Green-Red-IR (N-V-B-Y-R-I) ▪ Instruments with as few as four activated laser and 14 color parameters are available with the option to activate additional lasers and detection channels in the future with the purchase of an activation key ▪ For higher throughput applications an optional plate loader module is available and for use in regulated environments the software contains tools for 21 CFR Part 11 compliance Key Features ▪ Exquisite Sensitivity -Unique collection of innovative technologies provide exceptional detection capabilities -Large dynamic range to resolve dim and bright populations in the same sample -Use violet side scatter to detect nanoparticles ▪ Platform Versatility -Purchase the number of parameters needed now -Add more detection channels by purchasing an activation key -Includes full complement of repositionable bandpass filters, non-standard filters also available for even more flexibility -CytoFLEX LX WDM Beam Splitter module available to assign IR channels to UV, Near UV, or Violet laser WDM ▪ Low Maintenance -Lasers, steering optics and flow cell are all mounted onto a vibration isolated table, maintaining optical alignment -Low pressure fluidics system -Preventive Maintenance can be completed by the user, no service visit required ▪ Automation Enabled -Optional 96-well plate sample loader module -API (Application Programming Interface) allows external software to control the instrument -For automated sample processing and data acquisition integrate with the Biomek i-Series Instrument

CytoFLEX S Flow Cytometer

The CytoFLEX S Flow Cytometer series is an expansion of the CytoFLEX Platform. This model expands research possibilities, with a fourth laser option, multiple configurations and unique filter sets that allows investigators to focus on the science, not the instrumentation. Four different series are offered in this model. All instruments in the platform utilize CytExpert for CytoFLEX Acquisition and Analysis Software. ▪ Up to four lasers (488 nm, 638 nm, 405 nm, 561 nm, 375 nm, 808 nm ) with and 13 fluorescent detectors. ▪ Four series are available, Violet-Blue-Yellow Green-Red (V-B-Y-R), Near UV-Violet-Blue-Red (N-V-B-R),Near UV-Violet-Blue-Yellow Green (N-V-B-Y), and Violet-Blue-Red-IR (V-B-R-I) ▪ Activate as few as four parameters and upgrade later within the series up to 13 parameters ▪ For higher throughput applications an optional plate loader module is available and for use in regulated environments the software contains tools for 21 CFR Part 11 compliance Key Features ▪ Exquisite Sensitivity -Unique collection of innovative technologies provide exceptional detection capabilities -Large dynamic range to resolve dim and bright populations in the same sample -Use violet side scatter to detect nanoparticles ▪ Platform Versatility -Purchase the number of parameters needed now -Add more detection channels by purchasing an activation key -Includes full complement of repositionable bandpass filters, non-standard filters also available for even more flexibility ▪ Low Maintenance -Lasers, steering optics and flow cell are all mounted onto a vibration isolated table, maintaining optical alignment -Low pressure fluidics system -Preventive Maintenance can be completed by the user, no service visit required ▪ Automation Enabled -Optional 96-well plate sample loader module -API (Application Programming Interface) allows external software to control the instrument -For automated sample processing and data acquisition integrate with the Biomek i-Series Instrument

CytoFLEX SRT

CytoFLEX SRT Cell Sorter is a benchtop sorter that is capable of meeting requirements for a wide range of sorting needs. And like the CytoFLEX Platform, it includes innovative technologies that simplify the setup and operation, empowering investigators to focus on the research questions. The Violet-Blue-Yellow Green-Red (V-B-Y-R) Series has 15 fluorescent detectors when fully activated. It can be purchased with as few as five with an option to activate additional lasers and detectors with an activation key. It is capable of complex sort logic with different combinations of sort settings on each of four streams, including the ability to catch aborts of one of the other streams. An optional Biosafety Cabinet including aerosol evacuation or a standalone Aerosol Evacuation Unit is available. ▪ Capable of complex sort logic, including 4-way sorting, Mixed Mode sorting, and the ability to catch aborts and preserve precious cells ▪ Setup is smart and simplified, using automation to establish and maintain the sort stream ▪ Remote support ready using BeckmanConnect for on demand access to our technical specialists, perform many routine maintenance procedures independently

AQUIOS CL Flow Cytometry System

Sample preparation and data management usually are the major bottlenecks in routine flow cytometry. Even with a semi-automated process, you and your team may spend hundreds of hours per year for tasks that don’t add to your laboratory’s productivity. Application: TBNK Analysis, CD4 Testing Key Features -Work with a system that combines sample preparation and analysis in one compact platform. -Provide a 24/7 flow cytometry service as the AQUIOS CL can be run by less experienced operators. -Increase productivity with high-throughput performance that eliminates many of the least efficient features of existing systems. -Minimize the potential for user error inherent in existing systems that require numerous manual steps to set up and run. -Discover the AQUIOS Tetra System for Lymphocyte Subset Analysis, AQUIOS PLG or CD4 testing or automate your own user-defined assay with AQUIOS Designer Software. -AQUIOS CL Safety Features for Handling Potentially Biohazardous Sample Material

AMPure XP Reagent for PCR Purification

Cleanup and Size Selection You can use our proprietary SPRI paramagnetic bead-based chemistry to remove contaminants (dNTPs, salts, primers, primer dimers) throughout your NGS workflows. ▪ Used in a variety of NGS library prep chemistries ▪ Compatible with manual and automated processing ▪ High recovery of amplicons > 100 bp ▪ Predictable and consistent size selection AMPure XP Workflow

RNA and cDNA Cleanup

RNAClean XP Purify RNA and cDNA from common enzymatic reactions using our proprietary SPRI paramagnetic bead-based chemistry. ▪ Compatible with manual and automated processing ▪ Complete removal of salts, unincorporated primers and dNTPs ▪ Used in RNA-Seq library preparations ▪ Certified RNAse-free RNAClean XP Workflow Steps Overview RNAClean XP purifies cDNA and RNA from common enzymatic reactions. High Recovery Efficient recovery of your sample ensures that critical data is not lost within the workflow. Flexible Manual, hands-on cleanups using RNAClean XP require less than 30 minutes. Scalable For higher throughput needs, RNAClean XP is automated on Biomek platforms enabling hundreds of samples per day.

SPRIselect for Size Selection

Purify DNA fragments of the desired size for library preparation using our proprietary SPRI paramagnetic bead-based chemistry, which provides: ▪ Tunable fragment size selection to suit specific applications ▪ Predictable, consistent size selection between runs and reagent lots ▪ Compatibility with manual and automated processing Available in the following: SPRIselect 5mL SPRIselect 60ml SPRIselect 450ml SPRIselect Left Workflow SPRIselect Right Workflow Overview SPRIselect chemistry speeds and simplifies nucleic acid size selection for fragment library preparation for next-generation sequencing. Customizable Size Selection SPRIselect allows tunable size selection from 150 to 800 base pairs to adjust to specific workflow needs. Consistent Results SPRIselect yields consistent size selections without bead calibration between reagent lots. Flexible and Scalable Suitable for manual or automated workflows – the SPRIselect method can be run on a variety of Biomek platforms that offer minimal hands-on time.

EMnetik 24 System

DNA Cleanup for Genetic Engineering Monotonous, time-consuming column cleanup has been around since 1991—so a change is long overdue. And now it’s here. Replace your typical column cleanup steps with the benchtop EMnetik 24 System. You’ll spend half the time on PCR cleanup, which means you’ll have more time for the important activities in your lab. Bring your PCR cleanup and plasmid prep into the 21st century. Benefits of the EMnetik System: ▪ ~2x faster turnaround time compared to column cleanups (16 min vs 30 min) ▪ >80% recovery (comparable to column cleanup kits) ▪ Significantly fewer touchpoints (< 50 touchpoints compared to 300 for columns) ▪ No need to handle small columns or use a single-channel pipette ▪ Move samples from a thermocycler to the EMnetik 24 system, and don’t move them again until final elution ▪ Intuitive user interface removes guesswork by providing clear, step-by-step instructions Column-based cleanups are officially history.

FormaPure XL Total

DNA and RNA Extraction from FFPE Tissue FormaPure XL Total Extract DNA and RNA from the same formalin-fixed paraffin-embedded tissue sample using SPRI paramagnetic bead-based chemistry. FormaPure XL reagent kits are available in multiple kit sizes and extraction types based on your application and throughput needs. For optimum convenience, you also receive knowledgeable support for reagents and automation methods from a single vendor. ▪ Scalable, single-chemistry system compatible with manual and automated processing (including sample deparaffinization and lysis) ▪ Simple workflow with minimal hands-on-time ▪ Demonstrated flexibility to accommodate sample input variation ▪ High performance for yield, integrity and purity has been shown ▪ Performance demonstrated with a variety of sample and tissue types ▪ Demonstrated performance with 7x 10 μM curls FormaPure XL Total Visual Workflow

Biomek I5

Automated Workstation Optimize dependability and walk-away time. The Biomek i5 is a recent addition to our liquid handling portfolio, representing the best of what has made Biomek an industry leading brand – combined with enhancements suggested by customers around the globe. ▪ Ideal for medium- to high-throughput workflows ▪ 25 deck positions ▪ 0.5 μL-1,000 μL (Multichannel) or 0.5 μL-5,000 μL (Span-8) pipetting volume ranges ▪ Single Multichannel head (96/384) or Span-8 pipetting with gripper Versatile Workspace ▪ Open platform with grid-based deck ▪ Internal LED light illuminates workspace ▪ Automated Labware Positioners (ALPs) for sample processing ▪ Optional enclosed version to protect samples from airborne particles ▪ Integrate additional devices on- or off-deck ▪ Configurable for specific applications Flexible Pipetting & Workflow Management ▪ Multichannel head (96/384) or Span-8 pipetting ▪ Large-volume 1 mL multichannel pipetting head ▪ High-access, rotating gripper with unique offset finger design ▪ Disposable & fixed Biomek tips, including septum piercing ▪ Transfer volumes from 0.5 μL – 5,000 μL ▪ Independent Span-8 probe calibration ▪ 8 channel liquid-level sensing ▪ Supports labware from tubes to 1,536-well microplates ▪ Accurate intra-well pipetting Simple System Operation ▪ Easily automate existing processes and execute quick workflow changes ▪ Powered by icon-based software with data tracking and LIMS connectivity ▪ Windows 10 OS ▪ Extend walk-away operation with process management and scheduling software ▪ Automated deck framing ▪ Data-driven operations including hit-picking & normalization ▪ Light curtain safety feature ▪ Instrument status light bar ▪ DeckOptix cameras for live, remote-monitoring & on-error video capture Application-Focused Solutions ▪ Consultative workflow analysis ▪ Expert application & technical support ▪ Biomek automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows

Biomek I7

Automated Workstation The most powerful and comprehensive Biomek available. ▪ High-throughput ▪ 45 deck positions ▪ 0.5 – 5,000 μL pipetting volume range ▪ Single or dual heads Versatile Workspace ▪ Spacious, open-platform with grid-based deck ▪ Up to 45 deck positions ▪ Internal LED light ▪ Automated Labware Positioners (ALPs) for sample processing ▪ Optional enclosed version to protect samples from airborne particles ▪ Integrate additional devices on- or off-deck ▪ Configurable for specific applications Flexible Pipetting and Workflow Management ▪ Multiple single- & dual-arm configurations with Multichannel heads (96/384/Pin tool) and/or Span-8 pipetting ▪ Large-volume 1 mL multichannel pipetting head ▪ High-access, rotating gripper(s) with unique offset finger design ▪ Disposable & fixed Biomek pipette tips (including septum piercing) ▪ Transfer volumes from 0.5 μL – 5,000 μL ▪ Independent Span-8 probe calibration ▪ 8 channel liquid-level sensing ▪ Supports labware from tubes to 1,536-well microplates ▪ Accurate intra-well pipetting Simple System Operation ▪ Easily automate existing processes & execute quick workflow changes ▪ Powered by icon-based software with data tracking & LIMS connectivity ▪ Windows 10 OS ▪ Extend walk-away operation with process management and scheduling software ▪ Guided system setup ▪ Automated deck framing ▪ Data-driven method operations including hit-picking & normalization ▪ Light curtain safety feature ▪ Instrument status light bar ▪ DeckOptix cameras for live, remote-monitoring & on-error video capture Application-focused Solutions ▪ Consultative workflow analysis ▪ Expert application & technical support ▪ Biomek-automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows

Biomek 4000 Automated Liquid Handler

A compact liquid handler ideal for smaller laboratories and those new to automation. It helps standardize daily pipetting routines, maintain sample quality and generate repeatable, reliable results. Labs focused on genomics, drug discovery, cell biology, proteomics, forensics, and related research can run methods on the Biomek 4000 automated liquid handler. ▪ Ideal for low-throughput workflows ▪ 12 deck positions including 4 off-deck ▪ 1 – 1,000 μL pipetting volume range with liquid-level sensing ▪ Multiple interchangeable single- and eight-channel pipetting tools and gripper Versatile Workspace ▪ Compact design fits in laminar flow hood or on your lab bench ▪ Up to 12 deck positions including 4 off-deck position that can be used for the integration of thermal cycling, shaking, and waste disposal ▪ Add labware feeders to increase system capacity ▪ Optional enclosure to protect samples from airborne particles ▪ Configurable for specific applications Application-Focused Solutions Biomek-automated demonstrated methods and capabilities for genomic, drug discovery, basic research workflows, and more: ▪ NGS (B42929) ▪ PCR Set-up (B22637) ▪ PCR Clean-up (B22638) ▪ Cell Staining (B22639) ▪ Genomics (B22640) ▪ Liquid Handling (B22867) ▪ CE SDS Sample Prep (B37830) ▪ AC Prep (B37892) ▪ HLA Prep (C23350) Flexible Pipetting & Workflow Management ▪ Auto-interchangeable single- and 8-channel pipetting tools and gripper ▪ Dynamic volume pipetting range from 1 to 1000 μL ▪ Liquid-level sensing ▪ Supports labware from tubes to 384-well micro/macro and thermal cycling plates ▪ Directional pipetting to any location within the well with controlled aspiration and dispense rates ▪ Efficient wash and bulk dispense tool allows for dispensing against the wall of a well, tip touches, bulk dispense and per liquid volume calibration Simple System Operation ▪ Biomek Method Launch provides Icon-based programing for drag and drop method and labware loading ▪ Remote instrument monitoring through Google Chrome ▪ Biomek 3D simulator demonstrates method development in real time as you create it ▪ Data Management captures data needed for validation and integrates with LIMS system to import work orders and export data ▪ Optional Biomek Dart software allows live and historical data browsing and reduces manual data integration ▪ 21 CFR Part 11 approved

Biomek NGeniuS

Introducing Biomek NGeniuS Next Generation Library Prep System ▪ A flexible, easy-to-use liquid handler for NGS library preparation ▪ Increase walk-away time ▪ Processes up to 24 samples at a time ▪ Diverse menu of demonstrated application Key Features Automated NGS Workstation ▪ A simple, easy-to-use, purpose-built liquid handler for NGS library preparation. Biomek NGeniuS is ideal for laboratories requiring flexibility and less hands-on time. The user-friendly interface requires no programing skills. ▪ Reduces errors with Dynamic DeckOptix for guided labware placement and confirmation ▪ Increase walk-away time with an integrated thermal cycler, labware transport and reagent aliquoting ▪ Batch setup and system monitoring virtually anywhere from a Google Chrome or Microsoft Edge enabled computer using the Biomek NGeniuS portal ▪ Plug-and-play implementation in your lab with an array of library preparation kits from multiple vendors Reduce Errors ▪ Biomek NGeniuS virtually eliminates loading errors by combining the optical analytics of Dynamic DeckOptix and the user-friendly head-up display guiding users with real-time feedback on labware placement, ensuring correct deck loading, before automatically advancing to the next step. ▪ Have confidence in the setup while Dynamic DeckOptix labware and reagent identification checks for capped reagent vials, incorrect sample input reaction vessels, misplaced or un-removed plate covers, and missing thermal cycling pads. Minimize Hands-On Time ▪ Reduce the need to manually transfer reagents and automate most manual chemistry kits by loading reagents directly onto the reagent carousel ▪ Protect reagents from thermal degradation with temperature-controlled reagent storage allowing you to run end-to-end chemistries ▪ Extend walk-away time with integrated thermal cycler and labware transport ▪ Ensure the right tip for the right volume without manual intervention with Selective Tip Type to utilize both 96 and 384 configured tips Easy to Use ▪ Work-from-anywhere batch setup and system monitoring with the Biomek NGeniuS Portal software using a Google Chrome or Microsoft Edge enabled computer. ▪ No programing skills required for batch setup—simply name the batch, select the number of samples, from 4 to 24, make any necessary settings adjustments, select stop points—compatible with the method—that fits your schedule, upload your sample information, and you’re ready to go. ▪ Save time and effort by downloading a batch specific Work Aid to generate a simple check list which includes the reagents needed for the run, and instructions on how to prepare and load reagents and consumables. ▪ Turn and select on the system using the Software Navigation Dial to select the batch and you are ready to run ▪ Monitor the system status with 360° line of sight from the multicolor status light. If you are not in sight of your instrument, remotely monitor the system through the Biomek NGeniuS Portal using a Google Chrome or Microsoft Edge enabled computer. Flexibility ▪ Run the samples you have on hand now. Biomek NGeniuS can run any number of samples from 4-24, while minimizing reagent waste and providing the turnaround time needed for your lab ▪ Complimentary demonstrated application library is designed to evolve with your changing needs. ▪ Set-up and run multiple instruments from your Biomek NGeniuS Portal with network enabled scalability

Echo 525

Acoustic Liquid Handler ▪ For aqueous-based acoustic transfers ▪ Designed for biochemical and genomic sample and reagent transfer ▪ Improve data quality while saving on reagent costs ▪ Reagent reservoir for larger volume reagent transfers Read more about Echo Acoustic Technology here ▪ Key Benefits ▪ Highly precise and accurate low volume transfers enabling assay miniaturization ▪ Builds assays 50–100 times faster than traditional liquid handlers giving the lab higher capacity from one instrument ▪ Suite of Echo Software Applications guide creation of complex protocols for a variety of applications ▪ Eliminates pipetting variances that affect assay success ▪ Integrates into the Labcyte Access Laboratory Workstation for increased throughput ▪ Build Complex Assays Quickly ▪ The flexibility, speed, accuracy, and precision of the Echo 525 Liquid Handler enable researchers to build assays that are not possible with traditional liquid handlers. The use of acoustic sound energy removes the traditional boundaries of tip and pin tool based liquid handlers. Transfer variable fluid heights and viscosities from one source plate to enable rapid assay creation in one fluid transfer run. Say goodbye to fixed plate designs as the Echo Liquid Handler moves fluids from any well to any well enabling researchers to design the experimental plates they need to make new discoveries. ▪ Flexible and Reliable Transfer of Genomic Reagents ▪ The Echo 525 Liquid Handler transfers a wide range of fluids during one transfer including distilled water, buffers, nucleic acids, and reagents containing up to 50% glycerol. With its versatile fluid range, transfer volume range, any well to any well transfer capability, and powerful applications software the Echo 525 Liquid Handler supports a wide range of genomic assay workflows: ▪ Gene Synthesis ▪ PCR and qPCR assay set-up ▪ RNA and DNA NGS sequencing workflows ▪ Sanger sequencing assay set-up ▪ Single-cell sample preparation

Echo 650

Echo 650 Series Acoustic Liquid Handlers ▪ Enables assay miniaturization in a broad range of applications ▪ Transfer from 384-well and 1536-well microplates ▪ Accurate, precise, contact-free acoustic transfer in volumes as low as 2.5 nL ▪ Transfer from Echo Qualified sample tubes* and microplates ▪ Read more about Echo Acoustic Technology here * Available for tube-enabled models Key Benefits ▪ Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality ▪ Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer ▪ Accurate and precise transfer of nanoliter-scale quantities, enabling assay miniaturization, further reducing costs ▪ Better results through direct dilution of compounds, an improvement over serial dilution methods ▪ Flexibility to transfer any volume of liquid from any source well to any destination well Acoustic Sample Tube Management The FluidX AcoustiX Sample Tube (FAST) was developed in collaboration with and is sold by Brooks Life Sciences for ultra-high-density sample storage. The acoustic tube offers the following benefits: ▪ Echo Qualified design – compatible with Echo 650T and 655T Liquid Handlers ▪ Preserves sample integrity from storage to screen ▪ Miniaturize upstream liquid handling steps to conserve sample ▪ Rapidly pick sets of samples for targeted screening Workflow Automation To meet the broad spectrum of sample throughput needs, Echo 650 Series Liquid Handlers seamlessly integrate with the highly configurable AccessTM Dual Robot System accommodating a wide variety of devices and enabling a fully automated workflow. ▪ Configured to achieve optimal throughput for sample management workflows ▪ Compact and ergonomic design with docking modules, turntables, retractable shelves, and drawers ▪ Optional features can include environmental management to protect samples from hydration or evaporation The New Sound of Sample Management The Echo 655T Liquid Handler supports sample transfer directly from Echo Qualified sample tubes, enabling a fully non-contact liquid handling workflow from sample storage all the way to assay ready plates. The Echo 655T Liquid Handler is capable of transferring as little as 2.5 nL from 384-well and 1536-well microplates, and now, from sample tubes arrayed in a 96-tube format. Additionally, it transfers at the highest speed to meet the needs of high-thoughput biochemical and cell-based screening.

BioLector XT Microbioreactor

High-throughput microbioreactor enables real-time evaluation of biomass, fluorescence, pH, dissolved oxygen in the liquid phase (DO), and other key cultivation parameters for aerobes and anaerobes. Building on trusted BioLector Pro technology, the BioLector XT microbioreactor is based on a standard ANSI/SLAS (SBS) microtiter plate (MTP) format, and operates with online, pre-calibrated optical sensors. Disposable 48 well MTPs enable online measurement of cultivation parameters, while patented microfluidic technology supports simultaneous pH control and feeding. The optional microfluidic module eliminates manual liquid handling—no tubing or pipetting required, as everything is part of the gamma-radiated ready-to-use plate. Learn more about the BioLector XT microbioreactor: ▪ BioLector Learning Center ▪ Application Note: Anaerobic cultivation processes of probiotic bacteria in the BioLector XT microbioreactor ▪ Technical Data Sheet: BioLector XT microbioreactor ▪ Technical Data Sheet: Sealing Foil M2P-F-RSXT-10 ▪ Technical Note: Using the BioLector XT microbioreactor Gassing Lid ▪ Evolution Article: Learn about the history and evolution of the BioLector platform ▪ BioLector Modules: Easily upgrade the BioLector XT microbioreactor with additional modules ▪ Publications List Innovative New Gassing Head ▪ Enables fed-batch experiments under anaerobic conditions ▪ Gassing with O2 within a range of 1% – 100% and with CO2 within 1% – 12 % ▪ Reduces gas consumption to a few mL/minute ▪ Optional humidification of gases reduces evaporation Optional Microfluidic Module ▪ Unleashes full potential of the BioLector XT ▪ Complements online monitoring function with well-specific pH regulation/feeding ▪ Enables use of 2 reservoir wells per 4 cultivation wells ▪ Microvalves allot liquids at nanoliter-scale “Plug-and-play” Plate Design ▪ Real-time kinetics out of 48/32 parallel cultivations ▪ Customizable feeding strategies (batch, fed-batch, bolus, continuous)* ▪ Control of pH on-the-plate with pre-calibrated optical sensors* ▪ Small working volume (800 – 2400 μL) *Functionality requires optional microfluidic module Intelligent BioLection Software ▪ Intuitive user interface supports multi-user environments ▪ Free programming of all control parameters ▪ Open system enables live data downloads ▪ Fast processor ensures rapid download of experiment data

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