Waters
Alliance HPLC System
Defined by dependability – today, and in the future ▪ Time-tested, flexible, and reliable workhorse for your HPLC separations ▪ Integrated solvent and sample management with consistent system-to-system performance and high reproducibility ▪ A history of continued system improvements ensures the hightest in HPLC performance ▪ Simplify your daily LC system start-up with advanced software functionality Features and Benefits ▪ Quaternary solvent blending supports isocratic and gradient applications with 11 unique gradient profile curves. Blend up to 4 solvents in any proportion with Auto-Blend Technology. Compatible with a wide range of solvent types to support reversed-phase, normal-phase, GPC, SEC, and IEX application. ▪ Advanced solvent delivery capabilities. Serial flow path with pulse-free solvent delivery without the use of dampeners. Online solvent degassing and automated solvent compressibility for accurate flow. Integrated seal wash for robustness operation with all solvent types is standard. ▪ Up to 120 vials housed in an optional, temperature-controlled environment. Active and user programmable needle wash for low carryover. Variable injection volumes from 0.1 to 100 uL standard, and up to 2 mL optional. Supports STAT samples and auto- addition. ▪ Optional column heating or heating/cooling. Get the flexibility of running multiple methods on demand with optional column switching. ▪ Quaternary solvent blending supports isocratic and gradient applications with 11 unique gradient profile curves. Blend up to 4 solvents in any proportion with Auto-Blend Technology. Compatible with a wide range of solvent types to support reversed-phase, normal-phase, GPC, SEC, and IEX application. ▪ Advanced solvent delivery capabilities. Serial flow path with pulse-free solvent delivery without the use of dampeners. Online solvent degassing and automated solvent compressibility for accurate flow. Integrated seal wash for robustness operation with all solvent types is standard. ▪ Up to 120 vials housed in an optional, temperature-controlled environment. Active and user programmable needle wash for low carryover. Variable injection volumes from 0.1 to 100 uL standard, and up to 2 mL optional. Supports STAT samples and auto- addition. ▪ Optional column heating or heating/cooling. Get the flexibility of running multiple methods on demand with optional column switching.
Waters
ARC HPLC System
Accurate analysis for all Ever-evolving regulations are impacting LC method approaches for product quality control and beyond. Count on the Arc HPLC System for high-efficiency separations and quality data to help meet your regulatory requirements with confidence. With the Arc HPLC, you can easily replicate and improve the performance of existing LC methods without compromising data quality, eliminating the burdens of older, less efficient LC systems for routine use. Rugged and dependable, Arc HPLC delivers the ideal balance of performance and value for right-the-first-time analysis and trusted test results: ▪ Enhance performance without redeveloping your method ▪ Run methods with greater robustness over traditional HPLCs ▪ Easily replicate, adjust, and enhance existing HPLC methods with low analyte carryover, high injection precision, and high back pressure tolerance ▪ Seamlessly receive transferred methods from other HPLC platforms, preserving analyte retention time and reproducibility of your analysis ▪ Support compliance with Empower Chromatography Data System (CDS), the gold standard, compliant-ready software that facilitates data review, eliminates burdensome compliance documentation, and improves the overall quality of laboratory data Features and Benefits ▪ High Performance Analytical Detectors A wide range of high performance detection capabilities, optimized to support the diversity of applications. Includes photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, conductivity, and mass detection. ▪ Gradient SmartStart Adjust the injection relative to the gradient start to emulate other HPLC systems’ dwell volumes, without the need to alter the gradient table. Successfully transfer most methods in just two injections. ▪ Quaternary Solvent Management Precise and accurate blending of up to four solvents with automated solvent compressibility compensation. Increase solvent flexibility with an optional, integrated solvent select valve, providing access to six additional solvents. ▪ Auto•Blend PlusTM technology Program gradients directly in terms of pH and ionic strength to minimize manual mobile phase preparation and reduce potential for human error in routine analysis. ▪ Column Technology Heating and cooling that supports columns up to 300 mm in a stable temperature environment for method repeatability from lab-to-lab. Optional and integrated column switching for up to three columns provides unattended column changeover. Simplify method screening and easily switch back and forth to support multiple methods on one system. ▪ Negligible Carryover Advanced flow-through needle design minimizes carryover by continuously cleansing the needle during run. User-configurable wash settings provide capability to address even ‘sticky’ compounds to help ensure a clean analysis of the current target sample. Designed for Robustness Integrated solvent degassing, seal wash, and fluidic path designed to reduce clogging associated with high salt content buffers for maximum uptime. Holistic Offerings Benefit from an integrated offering of industry-leading columns, chemistry and software solutions to meet the needs of virtually every HPLC application. ▪ Columns: The perfect pairing for high-quality separations ▪ Informatics: Get more from your data for more confident decisions ▪ Global Services: Committed to your success
Waters
ACQUITY Advanced Polymer Chromatography System
The Next Era in Polymer Separation ▪ Highest-resolution, size-based separations for chromatographic polymer characterization ▪ Improve data consistency and quality by enabling fast, daily calibration ▪ Automate method development with advanced system technologies ▪ Get more information about your polymer, faster than before Features and Benefits ▪ Accelerate innovation through high-resolution insight into your polymer separations on sub 3- μm, rigid, high-pore volume ACQUITY APC columns paired with the ultra-low system dispersion of the ACQUITY APC System. ▪ Optimize method development via rapid and automated solvent switching and aggressive solvent compatibility, which supports the harsh separation conditions associated with polymer analyses. ▪ Increase analytical scope and laboratory efficiency by leveraging one system to perform multiple applications, including basic LC, gradient, isocratic, reverse-phase and GPC. ▪ Gain more insight into your polymer samples through broad compatibility with a wide range of detection techniques and third-party advanced detectors, including refractive index, UV/visible, photodiode array, or evaporative light scattering, and compatibility with advanced techniques like multi-angle light scattering and viscometry. ▪ Reduce laboratory turnaround times for polymer samples by getting answers to your development labs, your manufacturing operations teams, and your customers 5-20x faster than traditional SEC/GPC. ▪ Simplify and optimize column bank calibration through standards that are matched to column bank MW ranges. ▪ Versatile column management allows you to automatically select up to two banks of ACQUITY APC columns and up to two banks of traditional GPC columns – all housed in a stable, temperature-controlled environment. ▪ Precise flow delivery of the isocratic solvent manager ensures accurate MW data, day after day.
Waters
ACQUITY UPC2 System
The ease of reversed phase meets the power of normal phase. With the ACQUITY UPC2 System, the orthogonal capability of normal-phase LC has been elevated to a mainstream technique: Convergence Chromatography. ▪ The chromatographic principles and selectivity of normal-phase LC ▪ The ease-of-use and method development simplicity of reversed-phase LC ▪ The use of gradients across the widest polarity range ▪ Chiral and achiral separations in one system, with unequaled speed and confidence Features and Benefits Bringing ease-of-use to normal-phase LC By providing the ability to precisely vary mobile phase strength, pressure, and temperature, the Waters ACQUITY UPC2 System gives scientists the power to better control the retention of analytes for separating, detecting, and quantifying structural analogs, isomers, and enantiomeric and diasteriomeric mixtures. The world’s first convergence chromatography system Unique in its capabilities, the pioneering ACQUITY UPC2 System delivers what the rest of the industry never could – a system, based on the principles of normal-phase LC, with the ease-of-use of reversed-phase LC, and purposefully built for analytical performance, placing convergence chromatography atop the list of separations tools in the kit of all analytical chemists. Retention mechanisms and orthogonality to RPLC Harnessing what’s now known as convergence chromatography, an evolution of the traditional SFC technique, the ACQUITY UPC2 System has the power to create selective separations of structurally similar chiral and achiral compounds. The miscibility of CO2with a wide range of polar and non-polar organic solvents has made the liquid CO2-based mobile phase versatile enough to separate a much wider range of compounds than reversed-phase LC, especially for mixtures containing polar compounds. Not only can CO2-based solvents be used with both polar and non-polar stationary phases, but chromatography can be influenced by modulating solvent gradients with a much wider choice of columns using the same mass spectrometry-compatible co-solvents. Being orthogonal to reversed-phase LC, UPC2 separations often show an inverse order of elution among groups of analytes. In combination with various detection techniques, this orthogonality is valuable for confirming analyte identity in complex matrices.
Waters
ACQUITY Arc System
HPLC and UHPLC method compatibility at the flip of a switch The ACQUITY Arc System is a quaternary-based, modern LC system for scientists working with established methods who are looking for the versatility and robustness required to bridge the gap between HPLC and UPLC while continuing to support validated assays. ▪ Regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument ▪ Get mass detection, without changing the way you work, with the ACQUITY QDa Detector ▪ Deploy the benefits of 2.x μm particle columns to boost the chromatographic performance of your methods ▪ On-demand mobile phase creation with Auto●Blend Plus Technology, eliminating the cumbersome and error-prone approach of manual preparation
Waters
Arc Premier System
See clearly and consistently, with confidence. Today’s scientists and lab managers need to confidently produce the most accurate, reliable and reproducible data. The Arc Premier System produces correct, robust results from the very first injection, reliably and easily. The Arc Premier System features the new, innovative technology of MaxPeak High Performance Surfaces (HPS) Technology, which effectively reduces non-specific adsorption due to metal interactions, without complicated mobile phases or laborious methods. The Arc Premier System sharpens chromatographic peaks for metal-sensitive compounds by eliminating secondary interactions from metals, resulting in: ▪ Improved compliance from higher quality data ▪ Faster, more reproducible, and accurate data integration ▪ Shorter time from sample to result, without conditioning
Waters
ACQUITY Premier System
▪ Maximizing the sensitivity, repeatability, and robustness of your LC and LC-MS applications is critical. The ACQUITY Premier System is the next evolution of the Performance LC System which include the ACQUITY UPLC H-Class PLUS and ACQUITY UPLC I-Class PLUS Systems. Along with the reliability, ruggedness, high quality, and configuration flexibility you expect from the ACQUITY UPLC PLUS Series, the ACQUITY Premier System delivers a step change in chromatographic performance, lab efficiency, and risk control. ▪ The ACQUITY Premier System features MaxPeak High Performance Surfaces (HPS) Technology, which offers improvements in separation and detection of metal-sensitive analytes, enabling you to minimize the risk of undetected analytes – for increased efficiency and confidence in your results. Overview ▪ Minimize risk of undetected analytes with MaxPeak High Performance Surfaces (HPS) Technology ▪ Decrease time-to-result and increase overall efficiency by eliminating time-consuming system and column passivation ▪ Improve peak shape and reproducibility for the most challenging metal-sensitive compounds ▪ Achieve high-precision injections with direct inject sampling ▪ Reduce time on method development ▪ Multi-software platform support options with Empower, MassLynx, and UNIFI
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ACQUITY UPLC H-Class PLUS System
Performance that advances your lab ▪ Improve laboratory productivity by transitioning methods to UPLC Technology ▪ Improve the characterization of your most complex samples through enhanced resolution ▪ Leverage advanced tools that simplify and streamline your method development workflow ▪ Improve precision with state-of-the-art high pressure binary or quaternary solvent blending ▪ Increase the analytical value of your samples by leveraging optical and mass information ▪ Match the need of your laboratory through support of your existing HPLC, UHPLC, and UPLC methods Features and Benefits ▪ Get the flexibility of multi-solvent blending with the Quaternary Solvent Manager (QSM), and blend four solvents in any combination or proportion. Expand to up to nine solvents with the optional and integrated solvent-select valve for even greater flexibility. Automated solvent compressibility allows you to run any solvent in any combination without loss in accuracy or precision. ▪ Deliver precise and accurate binary solvent blending with the Binary Solvent Manager (BSM) at pressures up to 15,000 psi. Two integrated solvent select valves provide access to a total of four solvents. Automated solvent compressibility, integrated solvent degassing, and programmable seal wash maximize flow accuracy, precision, and reliability. ▪ High-precision injections with direct inject sampling. The needle-in-flow path design ensures an accurate needle seal at high pressure. Injection volumes from 0.1 μL up to 1 mL are supported. Ultra-low carryover is managed through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers. ▪ Accurate temperature control across the entire column. Configurable for 1 to 6 columns, each housed in individual temperature controlled zones with active pre-heating and a temperature range of 4 to 90 °C. ▪ Low-dispersion detection capabilities. The ACQUITY UPLC H-Class PLUS System is the only LC system in the market with a wide range of detectors that have been optimized for true UPLC performance. Minimizing dispersion and optimizing the electronics and optical paths for the narrow UPLC peaks yields the highest sensitivity and repeatability with the most accurate quantification. ▪ Significantly reduce the time you spend in the prep lab by automating the formulation of mobile phases at specific pH and ionic strength from reservoirs of pure solvents or concentrated stock solutions using Auto•Blend Plus Technology, available with the ACQUITY UPLC H-Class PLUS Quaternary System. Compatible with reversed phase, IEX, and SEC, this technology makes routine analyses easier to manage and execute and streamlines method development and method robustness testing by allowing you to test even the smallest changes in pH and ionic strength without needing to make each individual buffer. ▪ Automatically manage gradient start time and pre-injection steps in parallel with SmartStart Technology. This allows you to compensate for system volume differences when transferring methods between different LC systems or to minimize inject-to-inject cycle times for high throughput applications. ▪ Gradient SmartStart Easily adjusts for system volume differences when transferring methods from an alternative LC system without alteration to the method table. ▪ Supported in Empower, Masslynx, UNIFI, and several 3rd party software packages.
Waters
ACQUITY UPLC I-Class PLUS System
Complex challenges, solved With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS provides new possibilities of maximizing the resolution and sensitivity of your methods; enhancing the characterization of your samples, while improving productivity to advance the science of your laboratory. ▪ Highly efficient, rapid separations are facilitated by industry-leading ultra-low dispersion and delay volume. ▪ Ultra-efficient, narrow peaks enhance the sensitivity of any mass spectrometer to simplify the characterization of the most complex samples. Features and Benefits ▪ Delivers precise and accurate binary solvent blending at pressures up to 18,000 psi. Two integrated solvent select valves provide access to a total of four solvents. Automated solvent compressibility, integrated solvent degassing, and programmable seal wash maximize flow accuracy, precision and reliability. ▪ Sample injection versatility, depending upon your application. Select a needle-in-flow path injector to maximize the injection volume range from 0.1 to 1000 μL. Select a loop-based injector to achieve the lowest inject-to-inject cycle times. Ultra-low carryover is managed through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers. ▪ Ideally suited for high-throughput applications with the addition of the sample organizer, expanding the capacity to up to 19 plates/7,296 samples. ▪ Accurate temperature across the entire column provided by advanced column management. Active pre-heating ensures accurate temperature across the entire column with a temperature range of 4 to 90 °C. Configurable in a single or dual column configuration with automated column switching, or optional two-position valves can be installed to support multi-dimensional (2D) chromatography. ▪ Wide range of low-dispersion detection capabilities that have been optimized for true UPLC performance by minimizing dispersion and optimizing the electronics and optical paths for accurate quantification of the narrow UPLC peaks with the highest sensitivity and repeatability. ▪ Improves the performance of any mass spectrometer with the highest chromatographic resolution which minimizes interference from co-elutions. ▪ Compliance ready. Qualification of laboratory instrumentation is an integral part of compliance with regulatory and quality standards such as GMP, GLP, ISO 17025, USP <1058>, and others. The ACQUITY UPLC I-Class PLUS System supports Waters Empower-based automated system qualification tool (SQT), which minimizes the time and cost associated with annual qualification. ▪ Supported in Empower, Masslynx, UNIFI, and several 3rd party software packages.
Waters
ACQUITY UPLC M-Class System
LET YOUR LC INLET DO THE WORK FOR YOUR NANO- TO MICROSCALE SEPARATIONS ▪ System of choice for sample-limited applications in proteomics and biomarker discovery ▪ Higher sensitivity for any MS ▪ Maximum amount of data from any sample ▪ Less sample preparation volume and cost ▪ Reduced solvent consumption ▪ Increased dynamic range ▪ Flexible configurations for HDX technology, 2D, and UV detection Features and Benefits ▪ The analysis you’ve always desired for nano- to microscale separations. The ACQUITY UPLC M-Class System delivers the most robust, reliable, and highest quality nano- to microscale UPLC separations to every laboratory performing LC/MS analyses. With unprecedented usability, the ACQUITY UPLC M-Class System enables laboratories to succeed in analyzing compounds that are severely limited in amount or availability, even amid a complex matrix over several orders of magnitude. Confidently achieve your laboratory goals with high-efficiency ACQUITY UPLC M-Class Columns ranging from 75 μm to 1 mm I.D. by using complementary mass spectrometry to support our full range of column I.D.’s, or run 300 μm to 1 mm I.D. columns with optical detection. The system also offers a range of flexible configurations for HDX technology, UV detection, and 2D analysis. ▪ Expand the dynamic range of your analysis with 2D separations. The ACQUITY UPLC M-Class System has streamlined 2D-LC separations with a highly intuitive menu-driven method setup, standardized separation chemistries, and intelligent valve operation. Expanding on the use of a novel 2D reversed phase/reversed phase (RP/RP) approach, where the first dimension is run at pH 10 and the second at pH 2, grants the ability to robustly increase sample throughput with MS-compatible eluents. ▪ Your inlet to MS. The ACQUITY UPLC M-Class System expands the performance of any nano- to microscale MS analysis. It increases the linear dynamic range of your analysis, resulting in better MS analyses by DDA or MSE. The direct(non split) automatic solvent flow control algorithms of the ACQUITY UPLC M-Class System provide pulse-less flow for increased retention time reproducibility. Sample integrity is maintained due the ACQUITY UPLC M-Class System’s non-reactive surfaces. New drivers for MassLynx Software integrate the system seamlessly into your existing workflows. Monitor protein conformation with HDX technology. The ACQUITY UPLC M-Class System can quantify small changes in protein conformation by extending its pressure range to enable a higher efficiency separation. The system allows for manual sample injection and integrates the steps of HDX from digestion and separation still integrates all the steps of HDX from sample prep to actual sequence determination, D2 uptake curves, and comparison plots with Waters, interactive, highly innovative DynamXTM HDX Data Analysis Software. HDX data has become an enabling technology that can be used to make business decisions about: ▪ Drug candidate binding to a protein target ▪ Biopharmaceutical product development ▪ Protein-protein interactions ▪ Intellectual Property
Waters
ACQUITY QDa Mass Detector
Press On to Bring the Power of Mass Detection to Your Lab With great detection power comes great possibility – Minimize the risk of unexpected coelutions or components and confirm trace components with the analytical confidence of mass detection. Enhance the analytical value and productivity of each analysis. ▪ Intuitive operation ▪ More information from every sample ▪ Effortless integration ▪ Increased efficiency ▪ Resolving complexity Intuitive Operation ACQUITY QDa is as intuitive as an optical detector, with the robustness to handle all of your analyses. Working in harmony with your chromatography, it is pre-optimized to work with your samples, without the sample-specific or user adjustments typical of traditional mass spectrometers. For the first time, any analytical scientist can consistently generate the highest quality mass spectral data, routinely without the need for any special training or expertise thus eliminating any need to contract out and wait for results from specialist analytical service laboratories. Features and Benefits Effortless integration The ACQUITY QDa Detector is compatible with all Waters ACQUITY UPLC, ACQUITY UPC2, Alliance HPLC, and purification LC and SFC systems. The ACQUITY QDa Mass Detector is complementary to your current Waters optical detectors including ACQUITY UPLC PDA, TUV, or FLR, or ACQUITY UPC2 PDA optical detectors. The mass spectral information combines seamlessly into the same workflow, routinely giving you more complete characterization of your separation. Process, interpret, visualize, and compare the most complex data, and turn it into meaningful information quickly and simply. The ACQUITY QDa Detector is fully compatible with Empower Software, our industry-leading chromatography data software platform. With integrated optical and mass detector data processing workflows, you can also interrogate mass spectral data in the same way and same workflow as you do PDA data. The ACQUITY QDa Detector is also fully compatible with MassLynx Software and its suite of Application Managers. Increased efficiency The only mass detector that integrates with and even fits on top of your instrument stack. Using less bench space, less floor space and less energy than a traditional mass spectrometer, it fits easily within your existing laboratory set up as part of your regular workflow. Even routine maintenance is minimized, maximizing your uptime.
Waters
RADIAN ASAP Direct Mass Detector
The Power of Knowing Now Whether you are looking to improve your drug discovery cycle, expand your client services, or simply become more competitive in your turnaround times; integrating direct MS analysis can drive multiple system-wide efficiencies helping to achieve your operational goals. Combining flexibility, ease of operation and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more. ▪ Simple operation and data interpretation ▪ Minimal sample preparation ▪ No separation required ▪ Real-time results and classification. Compact Without Compromise The RADIAN ASAP is a novel, dedicated direct analysis system specifically designed for rapid, easy and low-cost analysis of liquids and solids. Engineered using proven and robust single quadrupole mass spectrometry technology combined with the Atmospheric Pressure Solids Analysis Probe (ASAP), the RADIAN ASAP delivers quality and ease of use in a compact footprint. The single quadrupole mass detector provides high quality mass spectral data, without the need for any special training or expertise thus eliminating any need to contract out and wait for results from specialist analytical service laboratories. Applications Forensics Rapid triage of seized drug materials Knowing now with RADIAN ASAP and LiveID ensures crime labs can quickly screen samples against a library of known compounds for rapid, confident identification of illicit drugs. The sensitivity and selectivity of mass spectrometry provides confidence in detecting drugs with an easy, efficient triage workflow. Food & Environmental Assess food integrity The threat posed by food fraud has created additional demands on both the food industry and regulators to protect food consumers and maintain brand reputation. Knowing now with RADIAN ASAP and LiveID offers a powerful combination of mass spectrometry and chemometric modelling, which allows users to easily and efficiently screen samples and make quicker decisions. Chemicals and Materials Fast chemical analysis for improved formulation testing Knowing now with RADIAN ASAP and IonLynx supports QC and Development Labs in the chemical industry to reduce costs and increase efficiencies. Workflows, such as fast chemical analysis for improved formulation testing or material release testing, can be streamlined. Features including thermal gradient analysis are ideal for complex samples commonly seen in the chemical industry. Pharma Discovery reaction monitoring The demand to accelerate the drug discovery and development process has never been higher. Knowing now with RADIAN ASAP provides synthetic chemists easy access to mass spectral data for near instantaneous assessment of reaction progress and identification of purification fractions, increasing lab efficiency. LiveID – Authenticity Testing For customers investigating the authenticity, adulteration and quality of food or raw materials, LiveID uses statistical models to classify samples. First, authentic or verified samples are used to create and validate a statistical model. The validated model can then be used with test samples and generate live classifications. The output is a simple to interpret yes/no answer. LiveID – Library Matching LiveID is also capable of real time library matching workflows, where the software matches all compounds in the library against each sample analyzed, giving a score out of 1000, where values close to 1000 indicate it is likely the compound of interest is in the sample; lower scores indicate it is unlikely to be present in the sample Automated data processing and reporting OpenLynx processing provides user customizable processing capabilities to generate automated mass confirmation reports in either pdf, printed or browser format. IonLynx allows users to determine levels and relative ratios of analytes of interest in complex samples to aid decision making in QC and formulation monitoring. IonLynx provides automated processing and reporting of non-chromatographic data sets, such as those generated by RADIAN ASAP.
Waters
SQ Detector 2
Designed for the routine, prepared for the unexpected. Compatible with the broadest range of chromatography platforms and ionization sources, the SQ Detector 2 is the ultimate single quadrupole mass detector for chromatography. ▪ IntelliStartTM guarantees maximum system performance and usability for reproducible results ▪ A wide mass range enables uncompromised analysis of both low and high molecular weight species ▪ Versatile chromatographic options ensure compatibility with the broadest range of applications. ▪ Universal Ion Source Architecture offers easy compatibility with the widest range of analytes Features and Benefits Mass Detection that’s easy to live with IntelliStartTM Technology automates system setup so that non-expert users can acquire data with confidence that the system is operating optimally. An integrated system of fluidics, electronics, and software which continually monitors system performance, helps you tune for optimum sensitivity, creates optimized SIR analysis methods and enables easy reporting of whole system performance. Through a series of diagnostic checks, the MS detector can report when it is ready for use. Any failures trigger a red-light system status, which warns that action may be required before analysis can proceed. A mass range as wide as you would need With a mass range of 3000 Da, the SQ Detector 2 makes mass confirmation of large molecules easier than ever before, allowing you to see higher mass peaks and giving you more confidence in your mass assignments. Future-proofing for the innovations of tomorrow The universal ion source architecture of the SQ Detector 2 family allows the widest range of ionization techniques to be utilized as well as the very latest innovations in ionization technologies. You’ll have limitless choice in experimental options. When you need options and time is critical, the ion sources are quickly interchangeable and ready to use within minutes. Walk-up accessibility The OpenLynxTM Open Access Application Manager provides walk-up access for LC-MS operation in laboratories whose chemists have varying levels of instrumental analysis experience. OpenLynx also provides customizable batch processing to support the large amounts of data generated by high-throughput analyses. To accelerate the learning curve for instrument operation, OpenLynx leads you through sample submission, method selection, and reporting options. These routine analyses can be performed more efficiently when chemists submit their own samples, leaving instrumentation experts more time to focus on advanced analyses. Accurate, reliable purification FractionLynxTM Application Manager manages and automates your sample purification process. FractionLynx controls fraction collection and tracks your samples, their fractions, and associated data, all accessible through the FractionLynx browser. Offering flexible compound detection, fraction triggering and collection capabilities, you can tailor your purification system to your specific compound and laboratory needs utilizing several types of detection including MS, UV and ELSD, as well as various fraction triggering and collection options. FractionLynx is also compatible with OpenLynx Open Access to provide a simple walk-up purification solution. Versatile chromotography compatibility Designed for optimum compatibility with multiple chromatographic separation techniques, the SQ Detector 2 is perfectly placed to help you extract more knowledge from your analyses. The SQ Detector 2 is compatible with UPLC, UPC2, HPLC, GC, preparative HPLC and preparative SFC, as well as direct analysis with the ASAP probe. ZSprayTM source architecture Integral to the Universal Ionization Source, Waters’ patented ZSprayTM technology means that you get optimum performance and excellent reproducibility from your analysis. Providing exceptional resistance to contamination by involatile buffers, the unique dual orthogonal pathway gives superior separation of ions from neutrals, keeping the instrument cleaner for longer. This results in less down-time, higher laboratory efficiency, and better instrument utilization. Ensures the correct result every time Prepare – IntelliStartTM and QuanpediaTM enable rapid, automated set-up and checking of the system and all of its methods, coupled with automatically scheduling MRM transitions to maximize performance. Analyze – During analysis, QCMonitor will actively monitor the data in real time, taking action if any user specified tolerances are exceeded. Interpret – TargetLynx provides automated quantification and reporting, with automated highly visible flags reducing the possibility for error. Decide –TrendPlot enables you to visualize results over many days, weeks or months; providing valuable information on data trends and long term system performance.
Waters
Xevo TQ Absolute
Absolute power to easily quantitate your most challenging compounds Achieve absolute confidence to reach lower limits of quantitation even for challenging negative ionizing compounds with an instrument that delivers absolute performance – the Xevo TQ Absolute. An incredibly compact, more sustainable tandem quadrupole mass spectrometer, the Waters Xevo TQ Absolute enables your lab to achieve and maintain high performance and productivity. With the Xevo TQ Absolute’s consistent robustness, significantly increased sensitivity for negative ionizing compounds compared to the previous product, and flexible software options, your lab can achieve time and cost savings with reproducible, complete results. Overview ▪ Absolute performance: Achieve lower limits of quantitation to meet regulatory requirements with up to 15x more sensitivity for challenging negative ionizing compounds than the previous product. ▪ Absolute efficiency: Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses approximately 50% less electricity and gas and produces 50% less heat than most other high performance TQ mass spectrometry instruments on the market. ▪ Absolute productivity: Boost your productivity with flexible software solutions, including waters_connect, the modern, intuitive informatics platform that can save up to 50% of your data review time, while facilitating data integrity. ▪ Absolute confidence: Ensure consistent robustness and reproducibility so you can maintain performance and productivity over a longer time period. ▪ Recommended Use: Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.
Waters
Xevo TQ-GC Mass Spectrometry System
The perfect addition to your laboratory A robust EI and CI GC-MS/MS platform engineered to maximize uptime with: ▪ Minimal method development enabled by QuanpediaTM method database driven workflows ▪ High performance and reliable so you can easily surpass regulatory limits ▪ Rapid and mistake-proof source design to simplify maintenance tasks ▪ Maintain regulatory compliance with MassLynx security ▪ Reduce training time and costs with a single software workflow for LC-MS/MS and GC-MS/MS analysis ▪ Wide range of injection modes, including liquid, headspace and SPME analysis Maximized Uptime to Ensure your Success Ensuring you achieve reliable and predictable results is at the heart of the design of the Xevo TQ-GC. The system has been rigorously tested to ensure that you spend less time on routine maintenance, and that it can be scheduled to fit around the laboratory workload, maximizing uptime and minimizing disruption. To ensure you don’t spend precious time on lengthy instrument setup, intellistart health check informs you whether the system is ready to run injections and, if not, how the situation can be remedied. You need minimal tools for instrument maintenance and if any maintenance is needed it is not only quick, but mistake-proof.
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Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry
Transform your quantitative capabilities. Accessible reliable performance. High performance quantitation, accessible to all. Routine testing doesn’t have to be limited – maximize your performance by expanding your analytes per injection and extending your validated concentration range, without increasing your lab footprint. Delivering purpose driven performance, so you can: ▪ easily acquire and review your quantitative data to meet your analytical and regulatory needs ▪ target more analytes per injection and cover a wider concentration range ▪ develop robust methods and easily set up your system for analysis Reliable performance so you can meet your analytical and regulatory requirements Save time on reporting results by using technologies that can meet requirements first time and every time. The Xevo TQ-S cronos is extremely robust and includes new reversed geometry sample cone that maximizes uptime, using technology developed from our award-winning QDa mass detector Save time on method development and quantitative data review It’s easy to transfer methods onto the Xevo TQ-S cronos using QUANPEDIA software, which enables databases of compounds to be stored with the appropriate methods. Discover new updates to our quantitation software. ▪ New flags in TargetLynx summary bar make it easy to see any out-of-tolerance samples ▪ Link your acquisition to processing methods to automatically update MRM function numbers ▪ Automatically update QUANPEDIA retention times from processed TargetLynx data files More analytes per injection across a wider concentration range Quantify more compounds with each chromatographic run using ultra fast MRM acquisition rates of 555 MRM/s. Maximize laboratory efficiency by reducing the need to dilute and reinject in cases where components are present at extremely high concentrations with five orders of linear dynamic range. ▪ Data quality at speed – peak intensity from an acquisition rate of 555 MRM/s is no more than 25% less than the peak intensity from an acquisition rate of 50 MRM/s ▪ Wide linear dynamic range – quantifying samples with unknown analyte concentrations can be time consuming Multi-residue pesticide testing performance you can rely on An example of an application area that the Xevo TQ-S cronos excels in is multi-residue pesticide testing. Not only will the Xevo TQ-S cronos deliver accurate, precise results but it will also work day in, day out with minimal user intervention. ▪ 204 LC-amenable pesticides tested in cucumber, tomato and capsicum matrices ▪ Straightforward DisQuE (CEN) with PSA dSPE sample preparation ▪ 1 in 10 dilution of extracts for excellent long term performance ▪ Superior linearity and consistency of ion ratios to meet analytical and regulatory requirements
Waters
Xevo TQ-S micro Triple Quadrupole Mass Spectrometry
High Performance from a Compact Design with Rapid, Reliable and Reproducible Quantitative Data Revolutionary design has produced a tandem quadrupole instrument with a small footprint that delivers consistent low levels of quantitation with a wide dynamic range. ▪ Class-leading performance that can fit into any lab ▪ Quantify highly polar, ionic compounds in food ▪ Benefit from flexibility and compatibility across the board ▪ Robust performance, even with the most complex sample matrices Features and Benefits Class-leading performance that can fit into any lab From the inherently robust Xevo family of tandem quadrupole instruments, the Xevo TQ-S micro provides superior performance per square inch and exceptional analytical flexibility. The Xevo TQ-S micro is able to reproduce high quality analytical performance injection after injection, even with the most complex sample matrices. Reliable instrument operation maximizes laboratory efficiency, delivering outstanding sensitivity for such a compact instrument. Quantify highly polar, ionic compounds in food The Xevo TQ-S micro’s reliable quantitative performance is shown in this example for glyphosate in cucumber. Excellent quantitative performance over a suitable calibration range is achieved for matrix matched calibration curves overlaid, which have bracketed an analytical run of over 40 injections. All back calculated concentrations are well within the 20% deviation permitted by SANTE/11813/2017. Highlighted from the curve is an example of the excellent performance achieved for glyphosate in cucumber, relative to the original Xevo TQ-S micro, illustrating suitability for checking compliance with MRLs set around the globe and for use for due diligence by the food industry. Flexibility and compatibility across the board Achieve more with increased flexibility delivered through a wider range of source and inlet options. Coverage for every application area is guaranteed through compatibility with Waters Universal Ion Source Architecture including: ▪ ESI, APCI, ESCi ▪ UniSpray ▪ APGC ▪ ionKey/MS ▪ ASAP ▪ Nanoflow ESI Chromatographic versatility is guaranteed through compatibility with: ▪ ACQUITY UPLC H-Class PLUS, H-Class Bio PLUS, H-Class Binary PLUS ▪ ACQUITY UPLC I-Class PLUS ▪ ACQUITY UPC2 ▪ ACQUITY M-Class ▪ GC Inherent robustness Robust performance begins in the source with Z-Spray geometry, efficiently removing neutral molecules while drawing ions through the sample cone into the analyzer. The StepWave ion guide in the Xevo TQ-S micro is designed to cope with the challenges in the modern laboratory that are produced by high sample throughput and difficult matrices. Neutrals and gas load are passively removed for enhanced transmission with the ions actively transferred into the mass analyzer, improving sensitivity and robustness.
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Waters
Xevo TQ-XS Triple Quadrupole Mass Spectrometry
One system. Every analyte. All the time. Demands on analytical laboratories are changing and every laboratory needs to ensure it can keep pace with these changes. The Xevo® TQ-XS offers: ▪ StepWave XSTM ion guide that provides increased sensitivity for challenging compounds. ▪ Enhanced detection system with six orders of linear dynamic range to ensure sensitivity is accessible. ▪ Tool-free probe design reduces the time taken for any routine maintenance and provides improved reproducibility between users. Features and Benefits Reproducible, ultimate sensitivity quantitation Whether you are analyzing small or large molecules, single analytes or multiple panels of compounds, the Xevo TQ-XS will give you the results you need, first time and without complication. The new StepWave XS ion guide provides improved sensitivity that is reproducible for multiple injections and can provide reliable quantitation at the very lowest levels. StepWave XS ensures neutrals and gas load are passively removed for enhanced transmission, with the ions actively transferred into the mass analyser, improving sensitivity and robustness. The first stage is modified with a series of horizontal plates that allows a more controlled extraction of ions from the gas flow so that ions collide with gas molecules with less energy. A segmented quadrupole second stage focuses the ion beam to provide more efficient transmission of ions from the source to the detector. Pushing the boundaries – leading technology The key technologies that enable you to do more with your instrument start with UniSprayTM which ionizes a wider range of compounds than any other single technique. Combining wider compound coverage with an extremely easy to use source, UniSpray can deliver results to your laboratory for more compounds than before, without having to change source or probe. So you can spend more time delivering results and less time changing instrument parts. Robust results you can trust with the most demanding sample matrices The routine challenges of complex matrices are overcome by the Xevo TQ-XS which provides reproducible results injection after injection despite difficult sample matrices. In a study involving 2,000 injections of protein-precipitated plasma and analyzing sulphadimethoxine, there was little variation in peak area over the entire injection series with <3% RSD. This study aimed to reproduce the challenging conditions found in many analytical laboratories by also using a short dwell time of only 5 ms.
Waters
LC Prep 150 System
A versatile system to suit your purification requirements The LC Prep 150 System is the perfect fit-for-purpose solution for the rapid isolation and collection of your valuable complex samples with complete confidence. ▪ Purification – made simple ▪ Robust system performance with intuitive ChromScope Software ▪ Confidently scale methods from analytical to prep ▪ Rapidly process your complex mixtures with complete confidence Features ▪ Flexible solvent delivery options allowing binary or quaternary based pumps providing low-pressure multi-solvent blending or high pressure gradient mixing of flow rates up to 150 ml/min. ▪ Easy to use manual or automated sample injection options allow the versatility to accommodate a wide range of workload requirements. ▪ Identify and isolate your compounds of interest with the highly sensitive 2489 UV/Visible or 2998 Photodiode Array detectors, providing enhanced linear range to accommodate highly concentrated samples. ▪ Confidently purify sample loads of milligrams to grams when using internal column diameters of up to 50mm. ▪ Use the easy-to-navigate ChromScope software delivered with sample set wizard, stacked injection wizard, key fraction collection parameters, fraction simulation modeling, and customizable reporting with drop and drag features.
Waters
LC Prep AutoPurification System
Preparative-scale chromatography plays a critical role in applications where compounds must be synthesized, identified, isolated, purified, characterized, screened, and tested. Waters AutoPurification Systems offer scalable prep configurations, whether you want the specificity of mass-directed purification or inclusiveness of a UV system. The LC Prep AutoPurification System provides you with the flexibility of using high-throughput parallel runs for selective mass-directed fraction collection from hundreds of samples. With the LC Prep AutoPurification System, run samples around the clock with unprecedented versatility and consistency. ▪ Take the complexity out of purification with our versatile solutions that are capable of purifying micrograms to multigram quantities. ▪ Automatically process hundreds of samples – or just a few. ▪ Robust and reliable systems improve your ability to manage increasing workload demands, including unattended instrument operation. ▪ Flexible configurations enable easy scale-up from analytical to preparative chromatography. ▪ FractionLynx Application Manager automates the collection of detected fractions, tracks samples and fractions, and then presents the data in an easy-to-view format. The software can trigger collection using a variety of detector signals including UV/Visible, Evaporative Light Scattering (ELS), MS, and analog. ▪ User-friendly console and software features help you manage solvents and samples, whether you do manual or automated injections. ▪ Proprietary Optimum Bed Density (OBD) Column design offers the highest sample loading and unmatched column stability. ▪ Easy-to-upgrade systems help you bring the latest technologies to your lab.
Waters
SFC Prep 150 AP System
Designed for automated UV and/or MS-triggered purification The Prep 150 AP SFC System is the first and only commercially available preparative SFC system offering automated sample handling, column switching, fraction collection and tracking in an easy-to-use, open bed format. The Prep 150 AP SFC System provides routine compound purification for drug discovery labs using the MassLynx Software with FractionLynx Application Manager. This system offers fast separations, high resolution and high throughput. The inherent benefits of SFC, combined with Waters’ world renowned service and support provides users with a robust, cost effective solution to any purification lab. SFC Prep 150 AP System The SFC Prep 150 AP System automates the purification process by linking analytical pre- screen, purification and fraction re-analysis with AutoPurify in an “open access” setting. Stacked Injection capability is also available for the purification of large amounts of material delivering multiple injections and allowing for multiple peaks collected into separate vessels. Features ▪ QGM Low Pressure mixing Quaternary Gradient Pump: This pump delivers flowrates up to a maximum of 150mL/min as serves as the co-solvent delivery device for this system. P200X CO2 Pump: This is a high pressure delivery pump having dual stainless steel heads with a cam driven sapphire piston assembly; self priming check valves; presser sensor; pressure gauge; brushless motor and a rupture disc assembly. The pumps design lends itself to control based upon feedback from the pressure sensor and mass flowmeter. Modifier Stream Injector: This design supports customers requests of Modified Stream Injection ONLY. It’s function is to inject one sample at a time using a standard 2mL loop and a 5mL syringe. This device allows for settable air gaps on either side of the sample. The air gap functions as a buffer between the solvent and the sample decreasing dilution. 3767 Sample Manager: This module provides injection and collection capability in an open bed format. The system includes the fume hood assembly for the 3767 for CO2 management. Injection and collection racks must be ordered for the system. The specific racks required will be determined by your needs and requirements.
Waters
SFC Prep 150 Mgm System
A greener approach to high throughput purification Designed for high throughput, semi-prep to preparative scale purifications, the SFC Prep 150 Mgm System is made for repeat injection (bulk purification) of Chiral and Achiral compounds. It operates at flow rates higher than traditional HPLC systems without significant increases in back pressure, allowing for high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations. It is perfectly suited for laboratories seeking to adopt a greener approach to high throughput purification. The SFC Prep 150 Mgm System has a maximum flow rate, CO2 and co-solvent combined, up to 150 mL/minute allowing use of 19 mm and 30 mm columns. It also has capacity for six fraction collection positions (two liters each). Controlled by the Waters Chromscope 2.1 SFC Software running under Windows 10, the user can take advantage of a new intuitive graphical interface. The SFC Prep 150 Mgm System operates at flow rates higher than traditional HPLC systems without significant increases in back pressure, allowing for high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations. ChromScope v2.1 is an updated version of ChromScope Software that enables support of the Waters SFC Prep 150 Mgm System with the ACQUITY QDa Mass Detector. Additionally, this update adds support for ELSD and the ISM. The Waters SFC Prep 150 Mgm System is perfectly suited for laboratories seeking to adopt a greener approach to high throughput purification. The SFC Prep 150 Mgm System is the ideal choice when reduction of normal-phase solvent usage and disposal is a critically important step for purification laboratories wanting to become more environmentally friendly SFC systems utilize liquid carbon dioxide (CO2) as its main mobile phase in combination with one or more organic solvents resulting in faster equilibration, lower pressure drops across the column, solvent reduction and lower cost per sample. The process is reproducible and applicable to a wide range of compounds relevant in the Pharmaceutical, Life Sciences, Chemical Materials and Food & Environmental markets. System Features QGM Low Pressure mixing Quaternary Gradient Pump: This pump delivers flowrates up to a maximum of 150mL/min serves as the co-solvent delivery device for this system. P200X CO2 Pump: This is a high pressure delivery pump having dual stainless steel heads with a cam driven sapphire piston assembly; self priming check valves; presser sensor; pressure gauge; brushless motor and a rupture disc assembly. The pumps design lends itself to control based upon feedback from the pressure sensor and mass flowmeter. Modifier Stream Injector: This design supports customers requests of Modified Stream Injection ONLY. It’s function is to inject one sample at a time using a standard 2-mL loop and a 5-mL syringe. This device allows for settable air gaps on either side of the sample. The air gap functions as a buffer between the solvent and the sample decreasing dilution. Prep Collection Cabinet: This collection cabinet comes with a retractable front door allowing for easy insertion and removal of 2-Liter Fraction Bottles. It has an exhaust port located in the upper backside of the cabinet to easily fit laboratories around the world requiring exhaust. It comes standard with a removable spill tray. Effortless Integration with the ACQUITY QDa Mass Detector: The intuitive design of the ACQUITY QDa Mass Detector gives you the additional data you need without the cost and complexity of traditional mass spectrometry. Now you can have access to the analytical confidence from the selectivity that mass detection brings to your analysis.
Waters
SFC Prep 350 System
Waters’ suite of bulk-scale supercritical fluid chromatography (SFC) purification systems offers the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample. When faster and more cost-effective means sustainable business operations, SFC is the purification technique that makes the difference. The preparative-scale SFC Prep 350 System is an automated system that features co-solvent gradient, high pressure separators for quantitative recovery of purified products, such as enantiomers, complex synthetic chemicals and natural products. The system is designed for chiral and achiral separations. Features ▪ High pressure CO2 pump ▪ High pressure co-solvent pump ▪ Injection module ▪ UV-Vis detector ▪ Fraction collection module ▪ Automated Back Pressure Regulator (ABPR) ▪ ChromScope Software
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