DNA Cleanup for Genetic Engineering Monotonous, time-consuming column cleanup has been around since 1991—so a change is long overdue. And now it’s here. Replace your typical column cleanup steps with the benchtop EMnetik 24 System. You’ll spend half the time on PCR cleanup, which means you’ll have more time for the important activities in your lab. Bring your PCR cleanup and plasmid prep into the 21st century. Benefits of the EMnetik System: ▪ ~2x faster turnaround time compared to column cleanups (16 min vs 30 min) ▪ >80% recovery (comparable to column cleanup kits) ▪ Significantly fewer touchpoints (< 50 touchpoints compared to 300 for columns) ▪ No need to handle small columns or use a single-channel pipette ▪ Move samples from a thermocycler to the EMnetik 24 system, and don’t move them again until final elution ▪ Intuitive user interface removes guesswork by providing clear, step-by-step instructions Column-based cleanups are officially history.
DNA and RNA Extraction from FFPE Tissue FormaPure XL Total Extract DNA and RNA from the same formalin-fixed paraffin-embedded tissue sample using SPRI paramagnetic bead-based chemistry. FormaPure XL reagent kits are available in multiple kit sizes and extraction types based on your application and throughput needs. For optimum convenience, you also receive knowledgeable support for reagents and automation methods from a single vendor. ▪ Scalable, single-chemistry system compatible with manual and automated processing (including sample deparaffinization and lysis) ▪ Simple workflow with minimal hands-on-time ▪ Demonstrated flexibility to accommodate sample input variation ▪ High performance for yield, integrity and purity has been shown ▪ Performance demonstrated with a variety of sample and tissue types ▪ Demonstrated performance with 7x 10 μM curls FormaPure XL Total Visual Workflow
Automated Workstation Optimize dependability and walk-away time. The Biomek i5 is a recent addition to our liquid handling portfolio, representing the best of what has made Biomek an industry leading brand – combined with enhancements suggested by customers around the globe. ▪ Ideal for medium- to high-throughput workflows ▪ 25 deck positions ▪ 0.5 μL-1,000 μL (Multichannel) or 0.5 μL-5,000 μL (Span-8) pipetting volume ranges ▪ Single Multichannel head (96/384) or Span-8 pipetting with gripper Versatile Workspace ▪ Open platform with grid-based deck ▪ Internal LED light illuminates workspace ▪ Automated Labware Positioners (ALPs) for sample processing ▪ Optional enclosed version to protect samples from airborne particles ▪ Integrate additional devices on- or off-deck ▪ Configurable for specific applications Flexible Pipetting & Workflow Management ▪ Multichannel head (96/384) or Span-8 pipetting ▪ Large-volume 1 mL multichannel pipetting head ▪ High-access, rotating gripper with unique offset finger design ▪ Disposable & fixed Biomek tips, including septum piercing ▪ Transfer volumes from 0.5 μL – 5,000 μL ▪ Independent Span-8 probe calibration ▪ 8 channel liquid-level sensing ▪ Supports labware from tubes to 1,536-well microplates ▪ Accurate intra-well pipetting Simple System Operation ▪ Easily automate existing processes and execute quick workflow changes ▪ Powered by icon-based software with data tracking and LIMS connectivity ▪ Windows 10 OS ▪ Extend walk-away operation with process management and scheduling software ▪ Automated deck framing ▪ Data-driven operations including hit-picking & normalization ▪ Light curtain safety feature ▪ Instrument status light bar ▪ DeckOptix cameras for live, remote-monitoring & on-error video capture Application-Focused Solutions ▪ Consultative workflow analysis ▪ Expert application & technical support ▪ Biomek automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows
Automated Workstation The most powerful and comprehensive Biomek available. ▪ High-throughput ▪ 45 deck positions ▪ 0.5 – 5,000 μL pipetting volume range ▪ Single or dual heads Versatile Workspace ▪ Spacious, open-platform with grid-based deck ▪ Up to 45 deck positions ▪ Internal LED light ▪ Automated Labware Positioners (ALPs) for sample processing ▪ Optional enclosed version to protect samples from airborne particles ▪ Integrate additional devices on- or off-deck ▪ Configurable for specific applications Flexible Pipetting and Workflow Management ▪ Multiple single- & dual-arm configurations with Multichannel heads (96/384/Pin tool) and/or Span-8 pipetting ▪ Large-volume 1 mL multichannel pipetting head ▪ High-access, rotating gripper(s) with unique offset finger design ▪ Disposable & fixed Biomek pipette tips (including septum piercing) ▪ Transfer volumes from 0.5 μL – 5,000 μL ▪ Independent Span-8 probe calibration ▪ 8 channel liquid-level sensing ▪ Supports labware from tubes to 1,536-well microplates ▪ Accurate intra-well pipetting Simple System Operation ▪ Easily automate existing processes & execute quick workflow changes ▪ Powered by icon-based software with data tracking & LIMS connectivity ▪ Windows 10 OS ▪ Extend walk-away operation with process management and scheduling software ▪ Guided system setup ▪ Automated deck framing ▪ Data-driven method operations including hit-picking & normalization ▪ Light curtain safety feature ▪ Instrument status light bar ▪ DeckOptix cameras for live, remote-monitoring & on-error video capture Application-focused Solutions ▪ Consultative workflow analysis ▪ Expert application & technical support ▪ Biomek-automated demonstrated methods & capabilities for genomic, drug discovery & basic research workflows
A compact liquid handler ideal for smaller laboratories and those new to automation. It helps standardize daily pipetting routines, maintain sample quality and generate repeatable, reliable results. Labs focused on genomics, drug discovery, cell biology, proteomics, forensics, and related research can run methods on the Biomek 4000 automated liquid handler. ▪ Ideal for low-throughput workflows ▪ 12 deck positions including 4 off-deck ▪ 1 – 1,000 μL pipetting volume range with liquid-level sensing ▪ Multiple interchangeable single- and eight-channel pipetting tools and gripper Versatile Workspace ▪ Compact design fits in laminar flow hood or on your lab bench ▪ Up to 12 deck positions including 4 off-deck position that can be used for the integration of thermal cycling, shaking, and waste disposal ▪ Add labware feeders to increase system capacity ▪ Optional enclosure to protect samples from airborne particles ▪ Configurable for specific applications Application-Focused Solutions Biomek-automated demonstrated methods and capabilities for genomic, drug discovery, basic research workflows, and more: ▪ NGS (B42929) ▪ PCR Set-up (B22637) ▪ PCR Clean-up (B22638) ▪ Cell Staining (B22639) ▪ Genomics (B22640) ▪ Liquid Handling (B22867) ▪ CE SDS Sample Prep (B37830) ▪ AC Prep (B37892) ▪ HLA Prep (C23350) Flexible Pipetting & Workflow Management ▪ Auto-interchangeable single- and 8-channel pipetting tools and gripper ▪ Dynamic volume pipetting range from 1 to 1000 μL ▪ Liquid-level sensing ▪ Supports labware from tubes to 384-well micro/macro and thermal cycling plates ▪ Directional pipetting to any location within the well with controlled aspiration and dispense rates ▪ Efficient wash and bulk dispense tool allows for dispensing against the wall of a well, tip touches, bulk dispense and per liquid volume calibration Simple System Operation ▪ Biomek Method Launch provides Icon-based programing for drag and drop method and labware loading ▪ Remote instrument monitoring through Google Chrome ▪ Biomek 3D simulator demonstrates method development in real time as you create it ▪ Data Management captures data needed for validation and integrates with LIMS system to import work orders and export data ▪ Optional Biomek Dart software allows live and historical data browsing and reduces manual data integration ▪ 21 CFR Part 11 approved
Introducing Biomek NGeniuS Next Generation Library Prep System ▪ A flexible, easy-to-use liquid handler for NGS library preparation ▪ Increase walk-away time ▪ Processes up to 24 samples at a time ▪ Diverse menu of demonstrated application Key Features Automated NGS Workstation ▪ A simple, easy-to-use, purpose-built liquid handler for NGS library preparation. Biomek NGeniuS is ideal for laboratories requiring flexibility and less hands-on time. The user-friendly interface requires no programing skills. ▪ Reduces errors with Dynamic DeckOptix for guided labware placement and confirmation ▪ Increase walk-away time with an integrated thermal cycler, labware transport and reagent aliquoting ▪ Batch setup and system monitoring virtually anywhere from a Google Chrome or Microsoft Edge enabled computer using the Biomek NGeniuS portal ▪ Plug-and-play implementation in your lab with an array of library preparation kits from multiple vendors Reduce Errors ▪ Biomek NGeniuS virtually eliminates loading errors by combining the optical analytics of Dynamic DeckOptix and the user-friendly head-up display guiding users with real-time feedback on labware placement, ensuring correct deck loading, before automatically advancing to the next step. ▪ Have confidence in the setup while Dynamic DeckOptix labware and reagent identification checks for capped reagent vials, incorrect sample input reaction vessels, misplaced or un-removed plate covers, and missing thermal cycling pads. Minimize Hands-On Time ▪ Reduce the need to manually transfer reagents and automate most manual chemistry kits by loading reagents directly onto the reagent carousel ▪ Protect reagents from thermal degradation with temperature-controlled reagent storage allowing you to run end-to-end chemistries ▪ Extend walk-away time with integrated thermal cycler and labware transport ▪ Ensure the right tip for the right volume without manual intervention with Selective Tip Type to utilize both 96 and 384 configured tips Easy to Use ▪ Work-from-anywhere batch setup and system monitoring with the Biomek NGeniuS Portal software using a Google Chrome or Microsoft Edge enabled computer. ▪ No programing skills required for batch setup—simply name the batch, select the number of samples, from 4 to 24, make any necessary settings adjustments, select stop points—compatible with the method—that fits your schedule, upload your sample information, and you’re ready to go. ▪ Save time and effort by downloading a batch specific Work Aid to generate a simple check list which includes the reagents needed for the run, and instructions on how to prepare and load reagents and consumables. ▪ Turn and select on the system using the Software Navigation Dial to select the batch and you are ready to run ▪ Monitor the system status with 360° line of sight from the multicolor status light. If you are not in sight of your instrument, remotely monitor the system through the Biomek NGeniuS Portal using a Google Chrome or Microsoft Edge enabled computer. Flexibility ▪ Run the samples you have on hand now. Biomek NGeniuS can run any number of samples from 4-24, while minimizing reagent waste and providing the turnaround time needed for your lab ▪ Complimentary demonstrated application library is designed to evolve with your changing needs. ▪ Set-up and run multiple instruments from your Biomek NGeniuS Portal with network enabled scalability
Acoustic Liquid Handler ▪ For aqueous-based acoustic transfers ▪ Designed for biochemical and genomic sample and reagent transfer ▪ Improve data quality while saving on reagent costs ▪ Reagent reservoir for larger volume reagent transfers Read more about Echo Acoustic Technology here ▪ Key Benefits ▪ Highly precise and accurate low volume transfers enabling assay miniaturization ▪ Builds assays 50–100 times faster than traditional liquid handlers giving the lab higher capacity from one instrument ▪ Suite of Echo Software Applications guide creation of complex protocols for a variety of applications ▪ Eliminates pipetting variances that affect assay success ▪ Integrates into the Labcyte Access Laboratory Workstation for increased throughput ▪ Build Complex Assays Quickly ▪ The flexibility, speed, accuracy, and precision of the Echo 525 Liquid Handler enable researchers to build assays that are not possible with traditional liquid handlers. The use of acoustic sound energy removes the traditional boundaries of tip and pin tool based liquid handlers. Transfer variable fluid heights and viscosities from one source plate to enable rapid assay creation in one fluid transfer run. Say goodbye to fixed plate designs as the Echo Liquid Handler moves fluids from any well to any well enabling researchers to design the experimental plates they need to make new discoveries. ▪ Flexible and Reliable Transfer of Genomic Reagents ▪ The Echo 525 Liquid Handler transfers a wide range of fluids during one transfer including distilled water, buffers, nucleic acids, and reagents containing up to 50% glycerol. With its versatile fluid range, transfer volume range, any well to any well transfer capability, and powerful applications software the Echo 525 Liquid Handler supports a wide range of genomic assay workflows: ▪ Gene Synthesis ▪ PCR and qPCR assay set-up ▪ RNA and DNA NGS sequencing workflows ▪ Sanger sequencing assay set-up ▪ Single-cell sample preparation
Echo 650 Series Acoustic Liquid Handlers ▪ Enables assay miniaturization in a broad range of applications ▪ Transfer from 384-well and 1536-well microplates ▪ Accurate, precise, contact-free acoustic transfer in volumes as low as 2.5 nL ▪ Transfer from Echo Qualified sample tubes* and microplates ▪ Read more about Echo Acoustic Technology here * Available for tube-enabled models Key Benefits ▪ Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality ▪ Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer ▪ Accurate and precise transfer of nanoliter-scale quantities, enabling assay miniaturization, further reducing costs ▪ Better results through direct dilution of compounds, an improvement over serial dilution methods ▪ Flexibility to transfer any volume of liquid from any source well to any destination well Acoustic Sample Tube Management The FluidX AcoustiX Sample Tube (FAST) was developed in collaboration with and is sold by Brooks Life Sciences for ultra-high-density sample storage. The acoustic tube offers the following benefits: ▪ Echo Qualified design – compatible with Echo 650T and 655T Liquid Handlers ▪ Preserves sample integrity from storage to screen ▪ Miniaturize upstream liquid handling steps to conserve sample ▪ Rapidly pick sets of samples for targeted screening Workflow Automation To meet the broad spectrum of sample throughput needs, Echo 650 Series Liquid Handlers seamlessly integrate with the highly configurable AccessTM Dual Robot System accommodating a wide variety of devices and enabling a fully automated workflow. ▪ Configured to achieve optimal throughput for sample management workflows ▪ Compact and ergonomic design with docking modules, turntables, retractable shelves, and drawers ▪ Optional features can include environmental management to protect samples from hydration or evaporation The New Sound of Sample Management The Echo 655T Liquid Handler supports sample transfer directly from Echo Qualified sample tubes, enabling a fully non-contact liquid handling workflow from sample storage all the way to assay ready plates. The Echo 655T Liquid Handler is capable of transferring as little as 2.5 nL from 384-well and 1536-well microplates, and now, from sample tubes arrayed in a 96-tube format. Additionally, it transfers at the highest speed to meet the needs of high-thoughput biochemical and cell-based screening.
High-throughput microbioreactor enables real-time evaluation of biomass, fluorescence, pH, dissolved oxygen in the liquid phase (DO), and other key cultivation parameters for aerobes and anaerobes. Building on trusted BioLector Pro technology, the BioLector XT microbioreactor is based on a standard ANSI/SLAS (SBS) microtiter plate (MTP) format, and operates with online, pre-calibrated optical sensors. Disposable 48 well MTPs enable online measurement of cultivation parameters, while patented microfluidic technology supports simultaneous pH control and feeding. The optional microfluidic module eliminates manual liquid handling—no tubing or pipetting required, as everything is part of the gamma-radiated ready-to-use plate. Learn more about the BioLector XT microbioreactor: ▪ BioLector Learning Center ▪ Application Note: Anaerobic cultivation processes of probiotic bacteria in the BioLector XT microbioreactor ▪ Technical Data Sheet: BioLector XT microbioreactor ▪ Technical Data Sheet: Sealing Foil M2P-F-RSXT-10 ▪ Technical Note: Using the BioLector XT microbioreactor Gassing Lid ▪ Evolution Article: Learn about the history and evolution of the BioLector platform ▪ BioLector Modules: Easily upgrade the BioLector XT microbioreactor with additional modules ▪ Publications List Innovative New Gassing Head ▪ Enables fed-batch experiments under anaerobic conditions ▪ Gassing with O2 within a range of 1% – 100% and with CO2 within 1% – 12 % ▪ Reduces gas consumption to a few mL/minute ▪ Optional humidification of gases reduces evaporation Optional Microfluidic Module ▪ Unleashes full potential of the BioLector XT ▪ Complements online monitoring function with well-specific pH regulation/feeding ▪ Enables use of 2 reservoir wells per 4 cultivation wells ▪ Microvalves allot liquids at nanoliter-scale “Plug-and-play” Plate Design ▪ Real-time kinetics out of 48/32 parallel cultivations ▪ Customizable feeding strategies (batch, fed-batch, bolus, continuous)* ▪ Control of pH on-the-plate with pre-calibrated optical sensors* ▪ Small working volume (800 – 2400 μL) *Functionality requires optional microfluidic module Intelligent BioLection Software ▪ Intuitive user interface supports multi-user environments ▪ Free programming of all control parameters ▪ Open system enables live data downloads ▪ Fast processor ensures rapid download of experiment data
RainPhil, Inc. was established and incorporated in July 25, 2000. Our company is one of the trusted suppliers for Laboratory Equipment Apparatus for Biomedical and Life Science use in the Philippines.
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