• System of choice for sample-limited applications in proteomics and biomarker discovery
  • Higher sensitivity for any MS
  • Maximum amount of data  from any sample
  • Less sample preparation volume and cost
  • Reduced solvent consumption
  • Increased dynamic range
  • Flexible configurations for HDX technology2D, and UV detection

Features and Benefits

  • The analysis you’ve always desired for nano- to microscale separations.

    The ACQUITY UPLC M-Class System delivers the most robust, reliable, and highest quality nano- to microscale UPLC separations to every laboratory performing LC/MS analyses. With unprecedented usability, the ACQUITY UPLC M-Class System enables laboratories to succeed in analyzing compounds that are severely limited in amount or availability, even amid a complex matrix over several orders of magnitude.  

    Confidently achieve your laboratory goals with high-efficiency ACQUITY UPLC M-Class Columns ranging from 75 µm to 1 mm I.D. by using complementary mass spectrometry to support our full range of column I.D.’s, or run 300 µm to 1 mm I.D. columns with optical detection.

    The system also offers a range of flexible configurations for HDX technology, UV detection, and 2D analysis.

  • Expand the dynamic range of your analysis with 2D separations.

    The ACQUITY UPLC M-Class System has streamlined 2D-LC separations with a highly intuitive menu-driven method setup, standardized separation chemistries, and intelligent valve operation.  Expanding on the use of a novel 2D reversed phase/reversed phase (RP/RP) approach, where the first dimension is run at pH 10 and the second at pH 2, grants the ability to robustly increase sample throughput with MS-compatible eluents.

  • Your inlet to MS.

    The ACQUITY UPLC M-Class System expands the performance of any nano- to microscale MS analysis. It increases the linear dynamic range of your analysis, resulting in better MS analyses by DDA or MSE. The direct(non split) automatic solvent flow control algorithms of the ACQUITY UPLC M-Class System provide pulse-less flow for increased retention time reproducibility. Sample integrity is maintained due the ACQUITY UPLC M-Class System’s non-reactive surfaces.  New drivers for MassLynx Software integrate the system seamlessly into your existing workflows.

    Monitor protein conformation with HDX technology.

    The ACQUITY UPLC M-Class System can quantify small changes in protein conformation by extending its pressure range to enable a higher efficiency separation. The system allows for manual sample injection and integrates the steps of HDX from digestion and separation still integrates all the steps of HDX from sample prep to actual sequence determination, D2 uptake curves, and comparison plots with Waters, interactive, highly innovative DynamX™ HDX Data Analysis Software. 

    HDX data has become an enabling technology that can be used to make business decisions about:

    • Drug candidate binding to a protein target
    • Biopharmaceutical product development
    • Protein-protein interactions
    • Intellectual Property

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